Abstract Fungal laccases (EC 1.10. 3.2) are multi-copper oxidases that oxidize a wide
variety of substrates. Despite extensive studies, the molecular basis for their diverse activity …

Bacterial cells present a wide diversity of saccharides that decorate the cell surface and help
mediate interactions with the environment. Many Gram-negative cells express O-antigens …

Several decades after the discovery of the first antibiotic (penicillin) microbes have evolved
novel mechanisms of resistance; endangering not only our abilities to combat future …

Ebola, one of the deadliest known infectious diseases, was the root of epidemics in Western
Africa from 2013 to 2016. Like other deadly viruses in the family Filoviridae with a high …

Mycobacterium tuberculosis (Mtb) infections are causing serious health concerns worldwide.
Antituberculosis drug resistance threatens the current therapies and causes further need to …

Secondary metabolite of Aspergillus terreus, terreic acid, is a reported potent antibacterial
that was identified more than 60 years ago, but its cellular target (s) are still unknown. Here …

Selective control over Aβ production via γ-secretase modulators (GSM) is a promising
strategy for treating Alzheimer's disease, yet the specific binding sites and mechanism of …

This study aims at identifying novel chemical scaffolds as inhibitors specific to the
acetyltransferase domain of a bifunctional enzyme, Escherichia coli GlmU, involved in the …

Background: Multidrug resistant Gram negative pathogens pose a persistent threat to the
health care system and require investigation of new targets and molecules for the …

Bacterial infections are a major cause of mortality and morbidity in humans throughout the
world. Infections due to resistant bacterial strains such as methicillin-resistant …