In the present work, we report compilation and analysis of 245 drugs, including small and
macromolecules approved by the US FDA from 2015 until June 2020. Nearly 29% of the …

Chagas disease (CD) is caused by the protozoan parasite Trypanosoma cruzi that infects a
broad range of triatomines and mammalian species, including man. It afflicts 8 million …

Many first-line treatments for neglected tropical diseases identified by the World Health
Organization (WHO) are limited by one or more of the following: the development of drug …

Leaf-cutting ants of the Attini tribe are a major pest of agricultural and forestry productions in
the New World. Economic losses caused by these ants were estimated at several million …

Chagas disease is caused by a parasite, Trypanosoma cruzi, transmitted primarily by a
triatomine insect and affects approximately 8 million people in Latin American countries. The …

Drug discovery for neglected tropical diseases is carried out using both target-based and
phenotypic approaches. In this paper, target-based approaches are discussed, with a …

Tropical diseases today constitute a major health problem and a big challenge for drug
discovery. Because of the limited arsenal of effective antiparasitic agents and the frequent …

Chagas disease is a neglected tropical disease caused by the protozoan Trypanosoma
cruzi. Currently, only nitroheterocyclic nifurtimox (NFX) and benznidazole (BNZ) are …

In this review, we present the potential use of the heterocyclic oxadiazole rings in the design
and synthesis of new drugs to treat parasitic infections. We intend to compare herein all the …

Research efforts on the medicinal chemistry of vanadium have been mainly focused whether
on improving biodistribution and tolerability of the vanadium insulin-enhancing core or on …