HIV pathogenesis in the human female reproductive tract
Abstract Purpose of Review Women remain disproportionately affected by the HIV/AIDS
pandemic. The primary mechanism for HIV acquisition in women is sexual transmission, yet …
pandemic. The primary mechanism for HIV acquisition in women is sexual transmission, yet …
The effects of hormones and vaginal microflora on the glycome of the female genital tract: cervical-vaginal fluid
In this study, we characterized the glycome of cervical-vaginal fluid, collected with a
Catamenial cup. We quantified: glycosidase levels; sialic acid and high mannose specific …
Catamenial cup. We quantified: glycosidase levels; sialic acid and high mannose specific …
Intestinal damage precedes mucosal immune dysfunction in SIV infection
T Hensley-McBain, AR Berard, JA Manuzak… - Mucosal …, 2018 - nature.com
HIV and pathogenic SIV infection are characterized by mucosal dysfunction including
epithelial barrier damage, loss of Th17 cells, neutrophil infiltration, and microbial …
epithelial barrier damage, loss of Th17 cells, neutrophil infiltration, and microbial …
Serum estradiol levels in controlled ovarian stimulation directly affect the endometrium
Previous studies have shown that increasing estradiol concentrations had a toxic effect on
the embryo and were deleterious to embryo adhesion. In this study, we evaluated the …
the embryo and were deleterious to embryo adhesion. In this study, we evaluated the …
[HTML][HTML] Translocating bacteria in SIV infection are not stochastic and preferentially express cytosine methyltransferases
Microbial translocation is a significant contributor to chronic inflammation in people living
with HIV (PLWH) and is associated with increased mortality and morbidity in individuals …
with HIV (PLWH) and is associated with increased mortality and morbidity in individuals …
Increased genital mucosal cytokines in Canadian women associate with higher antigen-presenting cells, inflammatory metabolites, epithelial barrier disruption, and …
C Farr Zuend, A Lamont, L Noel-Romas, S Knodel… - Microbiome, 2023 - Springer
Background Cervicovaginal inflammation has been linked to negative reproductive health
outcomes including the acquisition of HIV, other sexually transmitted infections, and cervical …
outcomes including the acquisition of HIV, other sexually transmitted infections, and cervical …
Structure-function relationships of the Neisserial EptA enzyme responsible for phosphoethanolamine decoration of lipid A: rationale for drug targeting
Bacteria cause disease by two general mechanisms: the action of their toxins on host cells
and induction of a pro-inflammatory response that can lead to a deleterious …
and induction of a pro-inflammatory response that can lead to a deleterious …
Molecular signatures of immune activation and epithelial barrier remodeling are enhanced during the luteal phase of the menstrual cycle: implications for HIV …
The variable infectivity and transmissibility of HIV/SHIV has been recently associated with
the menstrual cycle, with particular susceptibility observed during the luteal phase in …
the menstrual cycle, with particular susceptibility observed during the luteal phase in …
Effect of progestin-based contraceptives on HIV-associated vaginal immune biomarkers and microbiome in adolescent girls
MA Nasr, A Aldous, J Daniels, C Joy, E Capozzi… - Plos one, 2024 - journals.plos.org
Adolescent girls bear a disproportionate burden of both the HIV epidemic and unintended
pregnancies; yet important questions remain unanswered regarding the effects of hormonal …
pregnancies; yet important questions remain unanswered regarding the effects of hormonal …
Quantitative proteomic profiling of Cervicovaginal fluid from pregnant women with term and preterm birth
Background Preterm birth (PTB) is one of major causes of perinatal mortality and neonatal
morbidity, but knowledge of its complex etiology is still limited. Here we present …
morbidity, but knowledge of its complex etiology is still limited. Here we present …