Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date
several types of adipose tissue have been identified, namely white, brown, and beige, that …

The rising global prevalence of obesity, metabolic syndrome, and type 2 diabetes has driven
a sharp increase in non-alcoholic fatty liver disease (NAFLD), characterized by excessive fat …

The endocrine fibroblast growth factors (FGFs), FGF19, FGF21 and FGF23, are critical for
maintaining whole-body homeostasis, with roles in bile acid, glucose and lipid metabolism …

Since its identification in 2000, the interest of scientists in the hepatokine fibroblast growth
factor (FGF) 21 has tremendously grown, and still remains high, due to a wealth of very …

Background Muscle biopsy is the gold standard for diagnosis of mitochondrial disorders
because of the lack of sensitive biomarkers in serum. Fibroblast growth factor 21 (FGF-21) is …

Background—Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic
effects on glucose and lipid metabolism and insulin sensitivity. It acts as a key downstream …

Fibroblast growth factor (FGF) belongs to a large family of growth factors. FGFs use
paracrine or endocrine signaling to mediate a myriad of biological and pathophysiological …

Objective: To validate new mitochondrial myopathy serum biomarkers for diagnostic use.
Methods: We analyzed serum FGF21 (S-FGF21) and GDF15 from patients with (1) …

Summary Fibroblast growth factor 21 (FGF 21), a metabolic hormone predominantly
produced by the liver, is also expressed in adipocytes and the pancreas. It regulates glucose …

Fibroblast growth factor (FGF) family members are mostly secreted as signaling proteins with
diverse functions in development and metabolism. FGF21 is a unique FGF with metabolic …