Epigenetic regulation, mainly involving DNA methylation, histone modification, and
noncoding RNAs, affects gene expression without modifying the primary DNA sequence and …

Non-coding antisense transcripts arise from the strand opposite the sense strand. Over 70%
of the human genome generates non-coding antisense transcripts while less than 2% of the …

DNA methylation shapes the epigenetic landscape of the genome, plays critical roles in
regulating gene expression, and ensures transposon silencing. As is evidenced by the …

Extrasynaptic α5‐subunit containing GABAA (α5‐GABAA) receptors participate in chronic
pain. Previously, we reported a sex difference in the action of α5‐GABAA receptors in …

During pregnancy, the placenta is critical for the regulation of maternal homeostasis and
fetal growth and development. Exposures to environmental chemicals during pregnancy can …

DNA methylation is a crucial epigenetic modification that orchestrates chromatin remodelers
that suppress transcription, and aberrations in DNA methylation result in a variety of …

Histone lysine demethylases (KDMs) play a vital role in regulating chromatin dynamics and
transcription. KDM proteins are given modular activities by its sequence motifs with obvious …

Background Osteoarthritis is a chronic musculoskeletal disease characterized by age-
related gradual thinning and a high risk in females. Recent studies have shown that DNA …

Background Type 2 diabetes mellitus (T2DM) is caused by a combination of environmental,
genetic, and epigenetic factors including, fasting blood glucose (FBG), genetic variant …

Cerebral palsy (CP) is a severe type of brain disease affecting movement and posture.
Although CP has strong genetic and environmental components, considerable differences in …