The process of cellular differentiation requires the distinct spatial organization of the
microtubule cytoskeleton, the arrangement of which is specific to cell type. Microtubule …

The turn of the 21st century had witnessed a surge of interest in the centrosome and its
causal relation to human cancer development-a postulate that has existed for almost a …

Human breast tumours are diverse in their natural history and in their responsiveness to
treatments. Variation in transcriptional programs accounts for much of the biological diversity …

Multiple centrosomes in tumor cells create the potential for multipolar divisions that can lead
to aneuploidy and cell death. Nevertheless, many cancer cells successfully divide because …

Many human tumours show centrosome aberrations, indicating an underlying deregulation
of centrosome structure, duplication or segregation. Centrosomes organize microtubule …

Cilia and flagella are microtubule-based structures nucleated by modified centrioles termed
basal bodies. These biochemically complex organelles have more than 250 and 150 …

Aberrations in centrosome numbers have long been implicated in aneuploidy and
tumorigenesis, but their origins are unknown. Here we have examined how overexpression …

Over a century ago, centrosome aberrations were postulated to cause cancer by promoting
genome instability. The mechanisms governing centrosome assembly and function are …

Earlier studies of invasive breast tumors have shown that 60–80% are aneuploid and≈ 80%
exhibit amplified centrosomes. In this study, we investigated the relationship of centrosome …

Centrosomes are the major microtubule organising centres of animal cells. Deregulation in
their number occurs in cancer and was shown to trigger tumorigenesis in mice. However, the …