Transient and stable vector transfections have played important roles in illustrating the
function of specific genes/proteins. The general assumption is that such a platform could …

It has become apparent that the clinical success anticipated in the field of gene therapy has
been limited by progress in several of the fundamental areas of genetics, molecular and …

Cytogenetic evidence, in the form of deletions and balanced translocations, points to the
existence of a locus on 2q32–q33, for which haploinsufficiency results in isolated cleft palate …

CDP/Cux/Cut proteins are an evolutionarily conserved family of proteins containing several
DNA binding domains: one Cut homeodomain and one, two or three Cut repeats. In …

All jawed vertebrate species examined to date rely on a combination of innate and adaptive
immune systems to combat infectious organisms. The adaptive immune system consists of B …

The mammalian Cutl1 gene codes for the CCAAT displacement protein (CDP), which has
been implicated as a transcriptional repressor in diverse processes such as terminal …

Cux (Cut homeobox) genes are present in all metazoans. Early reports described many
phenotypes caused by cut mutations in Drosophila melanogaster. In vertebrates, CUX1 was …

Scaffold/matrix attachment regions (S/MARs) are DNA elements that serve to
compartmentalize the chromatin into structural and functional domains. These elements are …

CCAAT displacement protein (cux/CDP) is an atypical homeodomain protein that represses
expression of several developmentally regulated lymphoid and myeloid genes in vitro …

The peroxisome proliferator–activated receptor (PPAR) γ is essential for the formation and
function of adipocytes. It is also involved in regulating insulin sensitivity and is the functional …