Unleashing the power of optical attenuation coefficients to facilitate segmentation strategies in OCT imaging of age-related macular degeneration: perspective

PJ Rosenfeld, Y Cheng, M Shen, G Gregori… - Biomedical optics …, 2023 - opg.optica.org
The use of optical attenuation coefficients (OAC) in optical coherence tomography (OCT)
imaging of the retina has improved the segmentation of anatomic layers compared with …

Structural OCT and OCT angiography biomarkers associated with the development and progression of geographic atrophy in AMD

V Vallino, A Berni, A Coletto, S Serafino… - Graefe's Archive for …, 2024 - Springer
Background Geographic atrophy (GA) is an advanced, irreversible, and progressive form of
age-related macular degeneration (AMD). Structural optical coherence tomography (OCT) …

Onset and progression of persistent choroidal hypertransmission defects in intermediate age-related macular degeneration: a novel clinical trial endpoint

J Liu, M Shen, R Laiginhas, G Herrera, J Li… - American Journal of …, 2023 - Elsevier
Purpose The appearance and growth of persistent choroidal hypertransmission defects
(hyperTDs) detected on en face swept-source optical coherence tomography (SS-OCT) …

[HTML][HTML] Multimodal imaging and en face OCT detection of calcified drusen in eyes with age-related macular degeneration

J Liu, R Laiginhas, M Shen, Y Shi, J Li, O Trivizki… - Ophthalmology …, 2022 - Elsevier
Purpose En face OCT imaging was investigated as a method for the detection and
monitoring of calcified drusen in eyes with nonexudative age-related macular degeneration …

The total macular burden of hyperreflective foci and the onset of persistent choroidal hypertransmission defects in intermediate AMD

A Berni, M Shen, Y Cheng, G Herrera, F Hiya… - American journal of …, 2024 - Elsevier
Purpose The association between the total macular burden of hyperreflective foci (HRF) in
eyes with intermediate AMD (iAMD) and the onset of persistent choroidal hypertransmission …

Automated segmentation and quantification of calcified drusen in 3D swept source OCT imaging

J Lu, Y Cheng, J Li, Z Liu, M Shen, Q Zhang… - Biomedical optics …, 2023 - opg.optica.org
Qualitative and quantitative assessments of calcified drusen are clinically important for
determining the risk of disease progression in age-related macular degeneration (AMD) …

Depth-resolved visualization and automated quantification of hyperreflective foci on OCT scans using optical attenuation coefficients

H Zhou, J Liu, R Laiginhas, Q Zhang… - Biomedical optics …, 2022 - opg.optica.org
An automated depth-resolved algorithm using optical attenuation coefficients (OACs) was
developed to visualize, localize, and quantify hyperreflective foci (HRF) seen on OCT …

OCT prognostic biomarkers for progression to late age-related macular degeneration: a systematic review and meta-analysis

M Trinh, R Cheung, A Duong, L Nivison-Smith… - Ophthalmology Retina, 2023 - Elsevier
Topic To evaluate which OCT prognostic biomarkers best predict the risk of progression from
early/intermediate to late age-related macular degeneration (AMD). Clinical Relevance …

Hyperreflective foci in age-related macular degeneration are associated with disease severity and functional impairment

C Duic, K Pfau, TDL Keenan, H Wiley… - Ophthalmology …, 2023 - Elsevier
Purpose To analyze presence of hyperreflective foci (HRF) across different age-related
macular degeneration (AMD) severities and examine its correlation with other structural and …

[HTML][HTML] Comparison between Spectral-Domain and Swept-Source OCT Angiography for the Measurement of Persistent Hypertransmission Defects in Age-Related …

G Herrera, M Shen, O Trivizki, J Liu, Y Shi, FE Hiya… - Ophthalmology …, 2025 - Elsevier
Purpose Spectral-domain OCT angiography (SD-OCTA) scans were tested in an algorithm
developed for use with swept-source OCT angiography (SS-OCTA) scans to determine if SD …