In the past, conventional drug discovery strategies have been successfully employed to
develop new drugs, but the process from lead identification to clinical trials takes more than …

In silico tools, such as molecular docking, are widely applied to study interactions and
binding affinity of biological activity of proteins and peptides. However, restricted sampling of …

The de novo design of antimicrobial therapeutics involves the exploration of a vast chemical
repertoire to find compounds with broad-spectrum potency and low toxicity. Here, we report …

Proteins/peptides have shown to be promising therapeutic agents for a variety of diseases.
However, toxicity is one of the obstacles in protein/peptide-based therapy. The current study …

Artificial intelligence (AI) and machine learning (ML) models are being deployed in many
domains of society and have recently reached the field of drug discovery. Given the …

Agro-industrial by-products containing considerable amounts of protein (10–50%) such as
soybean meal, rice bran and coconut pulp are promising bioactive peptide sources with …

Toxicity emerges as a prominent challenge in the design of therapeutic peptides, causing
the failure of numerous peptides during clinical trials. In 2013, our group developed …

The rampant spread of COVID-19, an infectious disease caused by SARS-CoV-2, all over
the world has led to over millions of deaths, and devastated the social, financial and political …

Increasing use of therapeutic peptides for treating cancer has received considerable
attention of the scientific community in the recent years. The present study describes the in …

Motivation Recently, peptides have emerged as a promising class of pharmaceuticals for
various diseases treatment poised between traditional small molecule drugs and therapeutic …