In solid cancers, invasion and metastasis account for more than 90% of mortality. However,
in the current armory of anticancer therapies, a specific category of anti-invasion and …

The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

During metastasis, cancer cells disseminate to other parts of the body by entering the
bloodstream in a process that is called intravasation. They then extravasate at metastatic …

High parameter imaging is an important tool in the life sciences for both discovery and
healthcare applications. Imaging Mass Cytometry (IMC) and Multiplexed Ion Beam Imaging …

Exosomes are nano-sized membrane vesicles released by a variety of cell types, and are
thought to play important roles in intercellular communications. In breast cancer, through …

Cancer cells undergo genetic changes allowing their adaptation to environmental changes,
thereby obtaining an advantage during the long metastatic route, disseminated of several …

The behavior of cancer cells is strongly influenced by the properties of extracellular
microenvironments, including topology, mechanics and composition. As topological and …

Recent advances in tumor biology have revealed that a detailed analysis of the complex
interactions of tumor cells with their adjacent microenvironment (tumor stroma) is mandatory …

For metastasis to occur cells must communicate with to their local environment to initiate
growth and invasion. Exosomes have emerged as an important mediator of cell-to-cell …

Despite decades of research, the treatment and management of malignant tumors still
remain a formidable challenge for public health. New strategies for cancer treatment are …