HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer

GSR Raju, E Pavitra, SS Bandaru, GL Varaprasad… - Molecular cancer, 2023 - Springer
HOX transcript antisense intergenic RNA (HOTAIR) is an oncogenic non-coding RNA whose
expression is strongly correlated with the tumor grade and prognosis of a variety of …

HOTAIR: an oncogenic long non-coding RNA in human cancer

Q Tang, SS Hann - Cellular Physiology and Biochemistry, 2018 - karger.com
Abstract Long non-coding RNAs (LncRNAs) represent a novel class of noncoding RNAs that
are longer than 200 nucleotides without protein-coding potential and function as novel …

[HTML][HTML] lncRNA and breast cancer: Progress from identifying mechanisms to challenges and opportunities of clinical treatment

H **, W Du, W Huang, J Yan, Q Tang, Y Chen… - … Therapy-Nucleic Acids, 2021 - cell.com
Breast cancer is a malignant tumor that has a high mortality rate and mostly occurs in
women. Although significant progress has been made in the implementation of personalized …

HOX transcript antisense RNA (HOTAIR) in cancer

X Qu, S Alsager, Y Zhuo, B Shan - Cancer letters, 2019 - Elsevier
Long noncoding RNAs (lncRNAs) have emerged as a new family of master regulators of
cancer. The lncRNA HOX transcript antisense RNA (HOTAIR) is a prime example of an …

The lncRNA HOTAIR: a pleiotropic regulator of epithelial cell plasticity

L Amicone, A Marchetti, C Cicchini - Journal of Experimental & Clinical …, 2023 - Springer
The epithelial-to-mesenchymal transition (EMT) is a trans-differentiation process that
endows epithelial cells with mesenchymal properties, including motility and invasion …

[HTML][HTML] Gene regulation by antisense transcription: A focus on neurological and cancer diseases

S Najafi, SC Tan, P Raee, Y Rahmati… - Biomedicine & …, 2022 - Elsevier
Advances in high-throughput sequencing over the past decades have led to the
identification of thousands of non-coding RNAs (ncRNAs), which play a major role in …

[HTML][HTML] HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution

FC Kuo, MJ Neville, R Sabaratnam… - Cell reports, 2022 - cell.com
Mechanisms governing regional human adipose tissue (AT) development remain undefined.
Here, we show that the long non-coding RNA HOTAIR (HOX transcript antisense RNA) is …

The application of lncRNAs in cancer treatment and diagnosis

Y Zhang, L Tang - Recent patents on anti-cancer drug …, 2018 - ingentaconnect.com
Background: It is increasingly evident that lncRNAs have various biological functions playing
as essential regulators, getting involved in diverse cellular processes. Many of the lncRNAs …

[HTML][HTML] Long non-coding RNAs in osteosarcoma

R Chen, G Wang, Y Zheng, Y Hua, Z Cai - Oncotarget, 2017 - ncbi.nlm.nih.gov
Long non-coding RNAs (lncRNAs) with more than 200 nuleotides, have been explored to
participate in various cancer types including osteosarcoma (OS), which is the most common …

LncRNA HOTAIR in Tumor Microenvironment: What Role?

G Botti, G Scognamiglio, G Aquino, G Liguori… - International Journal of …, 2019 - mdpi.com
lncRNAs participate in many cellular processes, including regulation of gene expression at
the transcriptional and post-transcriptional levels. In addition, many lncRNAs can contribute …