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Neurodegeneration and demyelination in multiple sclerosis
Progressive multiple sclerosis (PMS) is an immune-initiated neurodegenerative condition
that lacks effective therapies. Although peripheral immune infiltration is a hallmark of …
that lacks effective therapies. Although peripheral immune infiltration is a hallmark of …
The complement system as a target in cancer immunotherapy
Malignant cells are part of a complex network within the tumor microenvironment, where
their interaction with host cells and soluble mediators, including complement components, is …
their interaction with host cells and soluble mediators, including complement components, is …
Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution
The Hydroxycarboxylic acid receptor 2 (HCA2), also known as the niacin receptor or
GPR109A, is a prototypical GPCR that plays a central role in the inhibition of lipolytic and …
GPR109A, is a prototypical GPCR that plays a central role in the inhibition of lipolytic and …
Molecular mechanism of distinct chemokine engagement and functional divergence of the human Duffy antigen receptor
The Duffy antigen receptor is a seven-transmembrane (7TM) protein expressed primarily at
the surface of red blood cells and displays strikingly promiscuous binding to multiple …
the surface of red blood cells and displays strikingly promiscuous binding to multiple …
Complement 3a receptor 1 on macrophages and Kupffer cells is not required for the pathogenesis of metabolic dysfunction-associated steatotic liver disease
Together with obesity and type 2 diabetes, metabolic dysfunction-associated steatotic liver
disease (MASLD) is a growing global epidemic. Activation of the complement system and …
disease (MASLD) is a growing global epidemic. Activation of the complement system and …
Functional profiling of the G protein-coupled receptor C3aR1 reveals ligand-mediated biased agonism
G protein-coupled receptors (GPCRs) are leading druggable targets for several medicines,
but many GPCRs are still untapped for their therapeutic potential due to poor understanding …
but many GPCRs are still untapped for their therapeutic potential due to poor understanding …
Molecular basis of promiscuous chemokine binding and structural mimicry at the CXC chemokine receptor, CXCR2
Selectivity of natural agonists for their cognate receptors is a hallmark of G-protein-coupled
receptors (GPCRs); however, this selectivity often breaks down at the chemokine receptors …
receptors (GPCRs); however, this selectivity often breaks down at the chemokine receptors …
Complement C3aR signaling: Immune and metabolic modulation and its impact on Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most
common cause of dementia among the elderly population. Despite its widespread …
common cause of dementia among the elderly population. Despite its widespread …
Biased signaling in GPCRs: Structural insights and implications for drug development
G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors in
humans, playing a crucial role in regulating diverse cellular processes and serving as …
humans, playing a crucial role in regulating diverse cellular processes and serving as …
The role and treatment potential of the complement pathway in chronic pain
The role of the complement system in pain syndromes has garnered attention on the back of
preclinical and clinical evidence supporting its potential as a target for new analgesic …
preclinical and clinical evidence supporting its potential as a target for new analgesic …