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Vaccine adjuvants: mechanisms and platforms
T Zhao, Y Cai, Y Jiang, X He, Y Wei, Y Yu… - Signal transduction and …, 2023 - nature.com
Adjuvants are indispensable components of vaccines. Despite being widely used in
vaccines, their action mechanisms are not yet clear. With a greater understanding of the …
vaccines, their action mechanisms are not yet clear. With a greater understanding of the …
Emerging concepts in the science of vaccine adjuvants
B Pulendran, P S. Arunachalam… - Nature reviews Drug …, 2021 - nature.com
Adjuvants are vaccine components that enhance the magnitude, breadth and durability of
the immune response. Following its introduction in the 1920s, alum remained the only …
the immune response. Following its introduction in the 1920s, alum remained the only …
[PDF][PDF] The PD-1/PD-L1-checkpoint restrains T cell immunity in tumor-draining lymph nodes
F Dammeijer, M van Gulijk, EE Mulder, M Lukkes… - Cancer cell, 2020 - cell.com
Summary PD-1/PD-L1-checkpoint blockade therapy is generally thought to relieve tumor cell-
mediated suppression in the tumor microenvironment but PD-L1 is also expressed on non …
mediated suppression in the tumor microenvironment but PD-L1 is also expressed on non …
The COVID-19 vaccine race: challenges and opportunities in vaccine formulation
J Wang, Y Peng, H Xu, Z Cui, RO Williams - Aaps Pharmscitech, 2020 - Springer
In the race for a safe and effective vaccine against coronavirus disease (COVID)-19,
pharmaceutical formulation science plays a critical role throughout the development …
pharmaceutical formulation science plays a critical role throughout the development …
Allergen immunotherapy in children user's guide
Allergen immunotherapy is a cornerstone in the treatment of allergic children. The clinical
efficiency relies on a well‐defined immunologic mechanism promoting regulatory T cells and …
efficiency relies on a well‐defined immunologic mechanism promoting regulatory T cells and …
Manganese salts function as potent adjuvants
Aluminum-containing adjuvants have been used for nearly 100 years to enhance immune
responses in billions of doses of vaccines. To date, only a few adjuvants have been …
responses in billions of doses of vaccines. To date, only a few adjuvants have been …
CCL5-producing migratory dendritic cells guide CCR5+ monocytes into the draining lymph nodes
Dendritic cells (DCs) and monocytes capture, transport, and present antigen to cognate T
cells in the draining lymph nodes (LNs) in a CCR7-dependent manner. Since only migratory …
cells in the draining lymph nodes (LNs) in a CCR7-dependent manner. Since only migratory …
Adjuvant physiochemistry and advanced nanotechnology for vaccine development
Vaccines comprising innovative adjuvants are rapidly reaching advanced translational
stages, such as the authorized nanotechnology adjuvants in mRNA vaccines against COVID …
stages, such as the authorized nanotechnology adjuvants in mRNA vaccines against COVID …
[HTML][HTML] Physiological functions and pathogenic potential of uric acid: A review
Uric acid is synthesized mainly in the liver, intestines and the vascular endothelium as the
end product of an exogenous pool of purines, and endogenously from damaged, dying and …
end product of an exogenous pool of purines, and endogenously from damaged, dying and …
Resolution of inflammation: a new therapeutic frontier
JN Fullerton, DW Gilroy - Nature reviews Drug discovery, 2016 - nature.com
Dysregulated inflammation is a central pathological process in diverse disease states.
Traditionally, therapeutic approaches have sought to modulate the pro-or anti-inflammatory …
Traditionally, therapeutic approaches have sought to modulate the pro-or anti-inflammatory …