The basophil activation test (BAT) is a functional assay that measures the degree of
degranulation following stimulation with allergen or controls by flow cytometry. It correlates …

Anaphylaxis is a severe systemic hypersensitivity reaction that is rapid in onset;
characterized by life-threatening airway, breathing, and/or circulatory problems; and usually …

Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967,
our knowledge about the immunological mechanisms of IgE‐mediated allergies has …

Background There is no widely adopted severity grading system for acute allergic reactions,
including anaphylactic and nonanaphylactic reactions, thus limiting the ability to optimize …

Background Food allergy is an increasing public health issue and the most common cause
of life-threatening anaphylactic reactions. Conventional allergy tests assess for the presence …

Basophils are the rarest granulocytes and have long been overlooked in immunological
research due to their rarity and similarities with tissue-resident mast cells. In the last two …

Mast cells and basophils are key contributors to allergies and other inflammatory diseases
since they are the most prominent source of histamine as well as numerous additional …

Anaphylaxis is a type I hypersensitivity reaction that is potentially fatal if not promptly treated.
It is a clinical diagnosis, although measurement of serial serum total mast cell tryptase (MCT) …

Food allergy is a public health issue the prevalence of which is steadily increasing. New
discoveries have contributed to the understanding of the molecular and cellular mechanisms …

Human basophils, first identified over 140 years ago, account for just 0.5-1% of circulating
leukocytes. While this scarcity long hampered basophil studies, innovations during the past …