Clustered regularly interspaced short palindromic repeats (CRISPR) system provides
adaptive immunity against plasmids and phages in prokaryotes. This system inspires the …

The transcriptional upregulation of oncogenes is a driving force behind the progression of
many tumours. However, until a decade ago, the concept of 'switching off'these oncogenic …

Bulk sequencing methodologies have allowed us to make great progress in cancer
research. Unfortunately, these techniques lack the resolution to fully unravel the epigenetic …

Therapy-induced DNA damage is the most common strategy to inhibit tumor cell
proliferation, but the therapeutic efficacy is limited by DNA repair machinery. Carrier-free …

Phenotypic plasticity associated with the hybrid epithelial–mesenchymal transition (EMT) is
crucial to metastatic seeding and outgrowth. However, the mechanisms governing the hybrid …

Inflammatory breast cancer (IBC) is a difficult-to-treat disease with poor clinical outcomes
due to high risk of metastasis and resistance to treatment. In breast cancer, CD44+ CD24 …

Large-scale genomic profiling of pancreatic cancer (PDAC) has revealed two distinct
subtypes:'classical'and 'basal-like'. Their variable coexistence within the stromal immune …

Bromodomain and extraterminal (BET) proteins bind acetylated lysine residues in histones
and nonhistone proteins via tandem bromodomains and regulate chromatin dynamics …

Triple negative breast cancer (TNBC) is a subtype of breast cancer, with estrogen receptor,
human epidermal growth factor receptor 2 and progesterone receptor negative. TNBC is …

Glioma is a primary aggressive brain tumor with high recurrence rate. The poor efficiency of
chemotherapeutic drugs crossing the blood‒brain barrier (BBB) is well-known as one of the …