The astounding world of glycans from giant viruses

I Speciale, A Notaro, C Abergel, R Lanzetta… - Chemical …, 2022 - ACS Publications
Viruses are a heterogeneous ensemble of entities, all sharing the need for a suitable host to
replicate. They are extremely diverse, varying in morphology, size, nature, and complexity of …

The flagellum attachment zone:'the cellular ruler'of trypanosome morphology

JD Sunter, K Gull - Trends in parasitology, 2016 - cell.com
A defining feature of Trypanosoma brucei cell shape is the lateral attachment of the
flagellum to the cell body, mediated by the flagellum attachment zone (FAZ). The FAZ is a …

New chemotherapy regimens and biomarkers for Chagas disease: the rationale and design of the TESEO study, an open-label, randomised, prospective, phase-2 …

C Alonso-Vega, JA Urbina, S Sanz, MJ Pinazo… - BMJ open, 2021 - bmjopen.bmj.com
Introduction Chagas disease (CD) affects~ 7 million people worldwide. Benznidazole (BZN)
and nifurtimox (NFX) are the only approved drugs for CD chemotherapy. Although both …

[HTML][HTML] Glycomics, glycoproteomics, and glycogenomics: an inter-taxa evolutionary perspective

CM West, D Malzl, A Hykollari, IBH Wilson - Molecular & Cellular …, 2021 - Elsevier
Glycosylation is a highly diverse set of co-and posttranslational modifications of proteins. For
mammalian glycoproteins, glycosylation is often site-, tissue-, and species-specific and …

[HTML][HTML] Rhamnose-containing compounds: biosynthesis and applications

S Li, F Chen, Y Li, L Wang, H Li, G Gu, E Li - Molecules, 2022 - mdpi.com
Rhamnose-associated molecules are attracting attention because they are present in
bacteria but not mammals, making them potentially useful as antibacterial agents …

Structure of N-linked oligosaccharides attached to chlorovirus PBCV-1 major capsid protein reveals unusual class of complex N-glycans

C De Castro, A Molinaro, F Piacente, JR Gurnon… - Proceedings of the …, 2013 - pnas.org
The major capsid protein Vp54 from the prototype chlorovirus Paramecium bursaria
chlorella virus 1 (PBCV-1) contains four Asn-linked glycans. The structure of the four N …

[HTML][HTML] The autonomous glycosylation of large DNA viruses

F Piacente, M Gaglianone, ME Laugieri… - International Journal of …, 2015 - mdpi.com
Glycosylation of surface molecules is a key feature of several eukaryotic viruses, which use
the host endoplasmic reticulum/Golgi apparatus to add carbohydrates to their nascent …

Anionic and zwitterionic moieties as widespread glycan modifications in non-vertebrates

K Paschinger, IBH Wilson - Glycoconjugate journal, 2020 - Springer
Glycan structures in non-vertebrates are highly variable; it can be assumed that this is a
product of evolution and speciation, not that it is just a random event. However, in animals …

The α-Galactosyl Carbohydrate Epitope in Pathogenic Protozoa

RM De Lederkremer, ME Giorgi… - ACS Infectious …, 2022 - ACS Publications
The α-gal epitope, which refers to the carbohydrate α-d-Gal p-(1→ 3)-β-d-Gal p-(1→ 4)-d-
GlcNAc-R, was first described in the glycoconjugates of mammals other than humans …

Analysis of zwitterionic and anionic N-linked glycans from invertebrates and protists by mass spectrometry

K Paschinger, IBH Wilson - Glycoconjugate journal, 2016 - Springer
Glycomic analyses over the years have revealed that non-vertebrate eukaryotes express
oligosaccharides with inorganic and zwitterionic modifications which are either occurring in …