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Molecular biology of Hodgkin lymphoma
Classical Hodgkin lymphoma (cHL) is unique among lymphoid malignancies in several key
biological features.(i) The Hodgkin and Reed-Sternberg (HRS) tumor cells are rare among …
biological features.(i) The Hodgkin and Reed-Sternberg (HRS) tumor cells are rare among …
The balance of TNF mediated pathways regulates inflammatory cell death signaling in healthy and diseased tissues
Tumor necrosis factor alpha (TNF; TNFα) is a critical regulator of immune responses in
healthy organisms and in disease. TNF is involved in the development and proper …
healthy organisms and in disease. TNF is involved in the development and proper …
Follicular lymphoma
Follicular lymphoma (FL) is a systemic neoplasm of the lymphoid tissue displaying germinal
centre (GC) B cell differentiation. FL represents~ 5% of all haematological neoplasms and …
centre (GC) B cell differentiation. FL represents~ 5% of all haematological neoplasms and …
Inhibitory feedback control of NF-κB signalling in health and disease
Cells must adapt to changes in their environment to maintain cell, tissue and organismal
integrity in the face of mechanical, chemical or microbiological stress. Nuclear factor-κB (NF …
integrity in the face of mechanical, chemical or microbiological stress. Nuclear factor-κB (NF …
Disorders of ubiquitylation: unchained inflammation
Ubiquitylation is an essential post-translational modification that regulates intracellular
signalling networks by triggering proteasomal substrate degradation, changing the activity of …
signalling networks by triggering proteasomal substrate degradation, changing the activity of …
Toll-like receptor signaling pathways
Toll-like receptors (TLRs) play crucial roles in the innate immune system by recognizing
pathogen-associated molecular patterns derived from various microbes. TLRs signal …
pathogen-associated molecular patterns derived from various microbes. TLRs signal …
Ibrutinib unmasks critical role of Bruton tyrosine kinase in primary CNS lymphoma
Bruton tyrosine kinase (BTK) links the B-cell antigen receptor (BCR) and Toll-like receptors
with NF-κB. The role of BTK in primary central nervous system (CNS) lymphoma (PCNSL) is …
with NF-κB. The role of BTK in primary central nervous system (CNS) lymphoma (PCNSL) is …
Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease
Systemic autoinflammatory diseases are driven by abnormal activation of innate immunity.
Herein we describe a new disease caused by high-penetrance heterozygous germline …
Herein we describe a new disease caused by high-penetrance heterozygous germline …
Genetics of diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL), the most frequent subtype of lymphoid malignancy,
remains a significant clinical challenge, as∼ 30% of patients are not cured. Over the past …
remains a significant clinical challenge, as∼ 30% of patients are not cured. Over the past …
Diffuse large B-cell lymphoma: optimizing outcome in the context of clinical and biologic heterogeneity
Although the majority of patients with diffuse large B-cell lymphoma (DLBCL) can be cured
with standard rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R …
with standard rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R …