Aging is associated with specific impairments of learning and memory, some of which are
similar to those caused by hippocampal damage. Studies of the effects of aging on …

Normal aging is commonly associated with a decline in memory, especially for newly-
acquired information. Most frequently implicated in this age-related memory dysfunction is a …

Time-dependent, learning-related changes in hippocampal excitability were evaluated by
recording from rabbit CA1 pyramidal neurons in slices prepared at various times after …

This article examines the functional significance of Ca2+-dependent synaptic plasticity in
relation to compromised memory function during aging. Research characterizing an age …

McEchron, Matthew D. and John F. Disterhoft. Sequence of single neuron changes in CA1
hippocampus of rabbits during acquisition of trace eyeblink conditioned responses. J …

In vitro experiments indicate that intrinsic neuronal excitability, as evidenced by changes in
the post-burst afterhyperpolarization (AHP) and spike-frequency accommodation, is altered …

Shankar, Subbakrishna, Timothy J. Teyler, and Norman Robbins. Aging differentially alters
forms of long-term potentiation in rat hippocampal area CA1. J. Neurophysiol. 79: 334–341 …

Hippocampally-dependent trace eyeblink conditioning has been shown to be affected by
aging. Aging animals take more trials to acquire the association and are more likely to be …

Some of the best biomarkers of age-related cognitive decline are closely linked to synaptic
function and plasticity. This review highlights several age-related synaptic alterations as they …

Calcium is required for the function of all cells in the body, including neurons. Considerable
research has described the function of calcium in the regulation of numerous processes …