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Short-chain fatty acids in diseases
D Zhang, YP Jian, YN Zhang, Y Li, LT Gu… - Cell Communication and …, 2023 - Springer
Short-chain fatty acids (SCFAs) are the main metabolites produced by bacterial fermentation
of dietary fibre in the gastrointestinal tract. The absorption of SCFAs is mediated by substrate …
of dietary fibre in the gastrointestinal tract. The absorption of SCFAs is mediated by substrate …
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of …
Document Reviewers: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici
(Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luıs Bronze (Portugal), John …
(Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luıs Bronze (Portugal), John …
The gut microbiome and hypertension
A large body of evidence has emerged in the past decade supporting a role for the gut
microbiome in the regulation of blood pressure. The field has moved from association to …
microbiome in the regulation of blood pressure. The field has moved from association to …
TH17 cell heterogeneity and its role in tissue inflammation
Since their discovery almost two decades ago, interleukin-17-producing CD4+ T cells (TH17
cells) have been implicated in the pathogenesis of multiple autoimmune and inflammatory …
cells) have been implicated in the pathogenesis of multiple autoimmune and inflammatory …
The immunology of multiple sclerosis
Our incomplete understanding of the causes and pathways involved in the onset and
progression of multiple sclerosis (MS) limits our ability to effectively treat this complex …
progression of multiple sclerosis (MS) limits our ability to effectively treat this complex …
[HTML][HTML] Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity
The aryl hydrocarbon receptor (AhR) is a sensor of products of tryptophan metabolism and a
potent modulator of immunity. Here, we examined the impact of AhR in tumor-associated …
potent modulator of immunity. Here, we examined the impact of AhR in tumor-associated …
Immune and inflammatory mechanisms in hypertension
TJ Guzik, R Nosalski, P Maffia… - Nature Reviews …, 2024 - nature.com
Hypertension is a global health problem, with> 1.3 billion individuals with high blood
pressure worldwide. In this Review, we present an inflammatory paradigm for hypertension …
pressure worldwide. In this Review, we present an inflammatory paradigm for hypertension …
Microbiota-derived tryptophan catabolites mediate the chemopreventive effects of statins on colorectal cancer
Epidemiological studies have indicated an association between statin use and reduced
incidence of colorectal cancer (CRC), and work in preclinical models has demonstrated a …
incidence of colorectal cancer (CRC), and work in preclinical models has demonstrated a …
Microbiota-derived indoles alleviate intestinal inflammation and modulate microbiome by microbial cross-feeding
Background The host–microbiota interaction plays a crucial role in maintaining homeostasis
and disease susceptibility, and microbial tryptophan metabolites are potent modulators of …
and disease susceptibility, and microbial tryptophan metabolites are potent modulators of …