Cells exert, sense, and respond to physical forces through an astounding diversity of
mechanisms. Here we review recently developed tools to quantify the forces generated by …

Tissue morphogenesis requires the collective, coordinated motion and deformation of a
large number of cells. Vertex model simulations for tissue mechanics have been developed …

Living tissues are active, multifunctional materials capable of generating, sensing,
withstanding and responding to mechanical stress. These capabilities enable tissues to …

During animal development, cell-fate-specific changes in gene expression can modify the
material properties of a tissue and drive tissue morphogenesis. While mechanistic insights …

Tissue morphogenesis results from a tight interplay between gene expression, biochemical
signaling and mechanics. Although sequencing methods allow the generation of cell …

Increasing evidence shows that mechanical stresses are critical in regulating cell functions,
fate, and diseases. However, no methods exist that can quantify isotropic compressive …

We sought to understand how cells collectively elongate epithelial tubes. We first used 3D
culture and biosensor imaging to demonstrate that epithelial cells enrich Ras activity …

Recognizing the crucial role of mechanical regulation and forces in tissue development and
homeostasis has stirred a demand for in situ measurement of forces and stresses. Among …

Understanding the cellular organization of tissues is key to developmental biology. In order
to deal with this complex problem, researchers have taken advantage of reductionist …

Understanding morphogenesis strongly relies on the characterization of tissue topology and
mechanical properties deduced from imaging data. The development of new imaging …