Angiotensin‐converting enzyme 2 (ACE2), SARS‐CoV‐2 and the pathophysiology of coronavirus disease 2019 (COVID‐19)
Abstract Angiotensin‐converting enzyme 2 (ACE2) has been established as the functional
host receptor for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the virus …
host receptor for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the virus …
Update on new aspects of the renin-angiotensin system in hepatic fibrosis and portal hypertension: implications for novel therapeutic options
There is considerable experimental evidence that the renin angiotensin system (RAS) plays
a central role in both hepatic fibrogenesis and portal hypertension. Angiotensin converting …
a central role in both hepatic fibrogenesis and portal hypertension. Angiotensin converting …
Leptin levels in SARS-CoV-2 infection related respiratory failure: A cross-sectional study and a pathophysiological framework on the role of fat tissue
Obesity is a risk factor for SARS-CoV-2 infected patients to develop respiratory failure. Leptin
produced in visceral fat might play a role in the deterioration to mechanical ventilation. A …
produced in visceral fat might play a role in the deterioration to mechanical ventilation. A …
Identification and screening of potential ACE2 activating peptides from soybean protein isolate hydrolysate against Ang II-induced endothelial dysfunction
Angiotensin-converting enzyme 2 (ACE2) is a counterregulator against ACE by converting
angiotensin II (Ang II) to Ang-(1–7), and its down-regulation leads to endothelial dysfunction …
angiotensin II (Ang II) to Ang-(1–7), and its down-regulation leads to endothelial dysfunction …
Egg white-derived tripeptide IRW (Ile-Arg-Trp) is an activator of angiotensin converting enzyme 2
Angiotensin converting enzyme 2 (ACE2) plays beneficial roles in the renin angiotensin
aldosterone system. Our previous studies indicated that egg white-derived antihypertensive …
aldosterone system. Our previous studies indicated that egg white-derived antihypertensive …
Xanthenone, ACE2 activator, counteracted gentamicin-induced nephrotoxicity in rats: impact on oxidative stress and ACE2/Ang-(1–7) signaling
Nephrotoxicity is a rapid deterioration of kidney function due to exposure to nephrotoxic
drugs as gentamicin. Gentamicin increases the generation of reactive oxygen species (ROS) …
drugs as gentamicin. Gentamicin increases the generation of reactive oxygen species (ROS) …
Leptin and its actions on reproduction in males
IA Malik, D Durairajanayagam… - Asian Journal of …, 2019 - journals.lww.com
Leptin, an adipocyte-derived hormone, serves numerous physiological functions in the body,
particularly during puberty and reproduction. The exact mechanism by which leptin activates …
particularly during puberty and reproduction. The exact mechanism by which leptin activates …
Impact of the ACE2 activator xanthenone on tacrolimus nephrotoxicity: modulation of uric acid/ERK/p38 MAPK and Nrf2/SOD3/GCLC signaling pathways
Aims The calcineurin inhibitor tacrolimus is an effective and widely used
immunosuppressant after organ transplantation to reduce graft rejection. However, its …
immunosuppressant after organ transplantation to reduce graft rejection. However, its …
Leptin and chronic kidney diseases
S Mao, L Fang, F Liu, S Jiang, L Wu… - Journal of Receptors …, 2018 - Taylor & Francis
Chronic kidney diseases (CKD), a common outcome of various kidney diseases, cause a
series of refractory complications, which lead to great economic burdens on patients. The …
series of refractory complications, which lead to great economic burdens on patients. The …
Uterine artery dysfunction in pregnant ACE2 knockout mice is associated with placental hypoxia and reduced umbilical blood flow velocity
Angiotensin-converting enzyme 2 (ACE2) knockout is associated with reduced fetal weight
at late gestation; however, whether uteroplacental vascular and/or hemodynamic …
at late gestation; however, whether uteroplacental vascular and/or hemodynamic …