Enhancer of zeste homolog 2 (EZH2) is enzymatic catalytic subunit of polycomb repressive
complex 2 (PRC2) that can alter downstream target genes expression by trimethylation of …

Non-coding RNAs (ncRNAs) are a large family of RNA molecules with no capability in
encoding proteins. However, they participate in developmental and biological processes …

Polycomb group (PcG) proteins are crucial chromatin regulators that maintain repression of
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …

Multiple, complex molecular events characterize cancer development and progression,.
Deciphering the molecular networks that distinguish organ-confined disease from metastatic …

Prostate cancer is a leading cause of cancer-related death in males and is second only to
lung cancer. Although effective surgical and radiation treatments exist for clinically localized …

The organization of chromatin into higher-order structures influences chromosome function
and epigenetic gene regulation. Higher-order chromatin has been proposed to be nucleated …

The Polycomb Group Protein EZH2 is a transcriptional repressor involved in controlling
cellular memory and has been linked to aggressive prostate cancer. Here we investigate the …

Enhancer of Zeste [E (z)] is a Polycomb-group transcriptional repressor and one of the
founding members of the family of SET domain-containing proteins. Several SET-domain …

Polycomb group (PcG) proteins maintain transcriptional repression during development,
likely by creating repressive chromatin states. The Extra Sex Combs (ESC) and Enhancer of …

Enhancer of Zeste is a Polycomb Group protein essential for the establishment and
maintenance of repression of homeotic and other genes. In the early embryo it is found in a …