Novel pathways for implantation and establishment and maintenance of pregnancy in mammals

FW Bazer, G Wu, TE Spencer… - MHR: Basic science …, 2009 - academic.oup.com
Uterine receptivity to implantation varies among species, and involves changes in
expression of genes that are coordinate with attachment of trophectoderm to uterine lumenal …

Interferons and progesterone for establishment and maintenance of pregnancy: interactions among novel cell signaling pathways

FW Bazer, RC Burghardt, GA Johnson, TE Spencer… - Reproductive …, 2008 - Elsevier
Type I and/or type II interferons (IFNs) are important in establishing uterine receptivity to
implantation in mammals. Gene expression effected by IFNs may be induced, stimulated or …

Single-cell analysis of menstrual endometrial tissues defines phenotypes associated with endometriosis

AJ Shih, RP Adelson, H Vashistha, H Khalili, A Nayyar… - BMC medicine, 2022 - Springer
Background Endometriosis is a common, complex disorder which is underrecognized and
subject to prolonged delays in diagnosis. It is accompanied by significant changes in the …

Conceptus-induced changes in the endometrial transcriptome: how soon does the cow know she is pregnant?

N Forde, F Carter, TE Spencer, FW Bazer… - Biology of …, 2011 - academic.oup.com
This study sought to determine the earliest response of the bovine uterine endometrium to
the presence of the conceptus at key developmental stages of early pregnancy. There were …

[PDF][PDF] Uterine receptivity to implantation of blastocysts in mammals

FW Bazer, TE Spencer, GA Johnson… - Front Biosci (Schol …, 2011 - academia.edu
[Frontiers in Bioscience S3, 745-767, January 1, 2011] 745 Uterine receptivity to implantation
of blastocysts in mammals Fuller Page 1 [Frontiers in Bioscience S3, 745-767, January 1 …

Uterine biology in pigs and sheep

FW Bazer, G Song, J Kim, KA Dunlap… - Journal of Animal …, 2012 - Springer
There is a dialogue between the develo** conceptus (embryo-fetus and associated
placental membranes) and maternal uterus which must be established during the peri …

Mechanisms for the establishment and maintenance of pregnancy: synergies from scientific collaborations

FW Bazer, RC Burghardt, GA Johnson… - Biology of …, 2018 - academic.oup.com
Research on the functions of interferon tau (IFNT) led to the theory of pregnancy recognition
signaling in ruminant species. But IFNT does much more as it induces expression of …

Loss of HGF/c-Met signaling in pancreatic β-cells leads to incomplete maternal β-cell adaptation and gestational diabetes mellitus

C Demirci, S Ernst, JC Alvarez-Perez, T Rosa… - Diabetes, 2012 - diabetesjournals.org
Hepatocyte growth factor (HGF) is a mitogen and insulinotropic agent for the β-cell.
However, whether HGF/c-Met has a role in maternal β-cell adaptation during pregnancy is …

Msx Homeobox Genes Critically Regulate Embryo Implantation by Controlling Paracrine Signaling between Uterine Stroma and Epithelium

S Nallasamy, Q Li, MK Bagchi, IC Bagchi - PLoS genetics, 2012 - journals.plos.org
The mammalian Msx homeobox genes, Msx1 and Msx2, encode transcription factors that
control organogenesis and tissue interactions during embryonic development. We observed …

Uterine histotroph and conceptus development: select nutrients and secreted phosphoprotein 1 affect mechanistic target of rapamycin cell signaling in ewes

FW Bazer, G Wu, GA Johnson, J Kim… - Biology of …, 2011 - academic.oup.com
Interferon tau (IFNT), the pregnancy recognition signal in ruminants, abrogates the uterine
luteolytic mechanism to ensure maintenance of function for the corpora lutea to produce …