Mendelian randomization for cardiovascular diseases: principles and applications

SC Larsson, AS Butterworth… - European heart journal, 2023 - academic.oup.com
Large-scale genome-wide association studies conducted over the last decade have
uncovered numerous genetic variants associated with cardiometabolic traits and risk factors …

Molecular aspects of fructose metabolism and metabolic disease

MA Herman, MJ Birnbaum - Cell metabolism, 2021 - cell.com
Excessive sugar consumption is increasingly considered as a contributor to the emerging
epidemics of obesity and the associated cardiometabolic disease. Sugar is added to the diet …

Coffee, caffeine, and health

RM van Dam, FB Hu, WC Willett - New England Journal of …, 2020 - Mass Medical Soc
Coffee, Caffeine, and Health In many countries, a large majority of adults consume caffeine
daily. This review summarizes the evidence about the varied physiological effects of caffeine …

Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration

JA Revez, T Lin, Z Qiao, A Xue, Y Holtz, Z Zhu… - Nature …, 2020 - nature.com
Vitamin D deficiency is a candidate risk factor for a range of adverse health outcomes. In a
genome-wide association study of 25 hydroxyvitamin D (25OHD) concentration in 417,580 …

Interindividual differences in caffeine metabolism and factors driving caffeine consumption

A Nehlig - Pharmacological reviews, 2018 - Elsevier
Most individuals adjust their caffeine intake according to the objective and subjective effects
induced by the methylxanthine. However, to reach the desired effects, the quantity of …

Acute effects of coffee consumption on health among ambulatory adults

GM Marcus, DG Rosenthal, G Nah… - … England Journal of …, 2023 - Mass Medical Soc
Background Coffee is one of the most commonly consumed beverages in the world, but the
acute health effects of coffee consumption remain uncertain. Methods We conducted a …

International society of sports nutrition position stand: caffeine and exercise performance

NS Guest, TA VanDusseldorp, MT Nelson… - Journal of the …, 2021 - Taylor & Francis
Following critical evaluation of the available literature to date, The International Society of
Sports Nutrition (ISSN) position regarding caffeine intake is as follows: Supplementation with …

Biomarkers of nutrition and health: new tools for new approaches

C Picó, F Serra, AM Rodríguez, J Keijer, A Palou - Nutrients, 2019 - mdpi.com
A main challenge in nutritional studies is the valid and reliable assessment of food intake, as
well as its effects on the body. Generally, food intake measurement is based on self-reported …

Implementing MR‐PRESSO and GCTA‐GSMR for pleiotropy assessment in Mendelian randomization studies from a practitioner's perspective

JS Ong, S MacGregor - Genetic epidemiology, 2019 - Wiley Online Library
With the advent of very large scale genome‐wide association studies (GWASs), the promise
of Mendelian randomization (MR) has begun to be fulfilled. However, whilst GWASs have …

Modifiable pathways in Alzheimer's disease: Mendelian randomisation analysis

SC Larsson, M Traylor, R Malik, M Dichgans… - bmj, 2017 - bmj.com
Objective To determine which potentially modifiable risk factors, including socioeconomic,
lifestyle/dietary, cardiometabolic, and inflammatory factors, are associated with Alzheimer's …