Fatty acid oxidation disorders (FAODs) are inborn errors of metabolism due to disruption of
either mitochondrial β-oxidation or the fatty acid transport using the carnitine transport …

We propose that plant foods containing high quantities of starch were essential for the
evolution of the human phenotype during the Pleistocene. Although previous studies have …

Underrepresentation of non-European (EUR) populations hinders growth of global precision
medicine. Resources such as imputation reference panels that match the study population …

High-coverage whole-genome sequence studies have so far focused on a limited number of
geographically restricted populations,,,, or been targeted at specific diseases, such as …

The indigenous people of Greenland, the Inuit, have lived for a long time in the extreme
conditions of the Arctic, including low annual temperatures, and with a specialized diet rich …

BACKGROUND When human populations expanded across the globe, they adapted
genetically to local environments in response to novel selection pressures. Drivers of …

It is commonly thought that human genetic diversity in non-African populations was shaped
primarily by an out-of-Africa dispersal 50–100 thousand yr ago (kya). Here, we present a …

Modern humans inhabit a variety of environments and are exposed to a plethora of selective
pressures, leading to multiple genetic adaptations to local environmental conditions. These …

One lead genetic risk signal of obesity—the rs1421085 T> C variant within the FTO gene—is
reported to be functional in vitro but lacks evidence at an organism level. Here we …

The ketogenic diet has recently received much attention for its promise of treating obesity
and type 2 diabetes. However, the enthusiasm for its potential benefits exceeds the current …