Organoids are in vitro miniaturized and simplified model systems of organs that have gained
enormous interest for modelling tissue development and disease, and for personalized …

Programmable genome integration of large, diverse DNA cargo without DNA repair of
exposed DNA double-strand breaks remains an unsolved challenge in genome editing. We …

Organoids bridge the gap between 2D cell lines and in vivo studies. With their 3D
organization and cellular heterogeneity, adult stem cell-derived organoids closely resemble …

We present a multiomic cell atlas of human lung development that combines single-cell RNA
and ATAC sequencing, high-throughput spatial transcriptomics, and single-cell imaging …

Variation in lung alveolar development is strongly linked to disease susceptibility. However,
underlying cellular and molecular mechanisms are difficult to study in humans. We have …

Germline–soma segregation is a fundamental event during mammalian embryonic
development. Here we establish the epigenetic principles of human primordial germ cell …

The balance between self‐renewal and differentiation in human foetal lung epithelial
progenitors controls the size and function of the adult organ. Moreover, progenitor cell gene …

Understanding the genetic basis of immunological processes and their overall dynamics
under the influence of population immunogenetics and host-microbe interactions has been …

Organoid technology allows the expansion of primary epithelial cells from normal and
diseased tissues, providing a unique model for human (patho) biology. In a three …

The global burden of respiratory diseases is very high and still on the rise, prompting the
need for accurate models for basic and translational research. Several model systems are …