Plasmalogens: A potential therapeutic target for neurodegenerative and cardiometabolic disease
Plasmalogens are a class of membrane glycerophospholipids with unique properties. They
contain a vinyl-ether linked alkyl chain at the sn-1 position of the glycerol backbone and …
contain a vinyl-ether linked alkyl chain at the sn-1 position of the glycerol backbone and …
Regulation of plasmalogen metabolism and traffic in mammals: The fog begins to lift
F Dorninger, ER Werner, J Berger… - Frontiers in Cell and …, 2022 - frontiersin.org
Due to their unique chemical structure, plasmalogens do not only exhibit distinct biophysical
and biochemical features, but require specialized pathways of biosynthesis and …
and biochemical features, but require specialized pathways of biosynthesis and …
Complement C5a induces renal injury in diabetic kidney disease by disrupting mitochondrial metabolic agility
The sequelae of diabetes include microvascular complications such as diabetic kidney
disease (DKD), which involves glucose-mediated renal injury associated with a disruption in …
disease (DKD), which involves glucose-mediated renal injury associated with a disruption in …
[HTML][HTML] IGF1–PI3K-induced physiological cardiac hypertrophy: Implications for new heart failure therapies, biomarkers, and predicting cardiotoxicity
Heart failure represents the end point of a variety of cardiovascular diseases. It is a growing
health burden and a leading cause of death worldwide. To date, limited treatment options …
health burden and a leading cause of death worldwide. To date, limited treatment options …
Plasmalogen replacement therapy
JC Bozelli Jr, RM Epand - Membranes, 2021 - mdpi.com
Plasmalogens, a subclass of glycerophospholipids containing a vinyl-ether bond, are one of
the major components of biological membranes. Changes in plasmalogen content and …
the major components of biological membranes. Changes in plasmalogen content and …
[HTML][HTML] Lipidomic profiles of the heart and circulation in response to exercise versus cardiac pathology: a resource of potential biomarkers and drug targets
Exercise-induced heart growth provides protection against cardiovascular disease, whereas
disease-induced heart growth leads to heart failure. These distinct forms of growth are …
disease-induced heart growth leads to heart failure. These distinct forms of growth are …
Advances in the biosynthetic pathways and application potential of plasmalogens in medicine
Y Zhou, N Yu, J Zhao, Z **e, Z Yang… - Frontiers in Cell and …, 2020 - frontiersin.org
Plasmalogens are a special class of polar glycerolipids containing a vinyl-ether bond and an
ester bond at sn-1 and sn-2 positions of the glycerol backbone, respectively. In animals …
ester bond at sn-1 and sn-2 positions of the glycerol backbone, respectively. In animals …
Phosphatidylethanolamine homeostasis under conditions of impaired CDP-ethanolamine pathway or phosphatidylserine decarboxylation
M St Germain, R Iraji, M Bakovic - Frontiers in Nutrition, 2023 - frontiersin.org
Phosphatidylethanolamine is the major inner-membrane lipid in the plasma and
mitochondrial membranes. It is synthesized in the endoplasmic reticulum from ethanolamine …
mitochondrial membranes. It is synthesized in the endoplasmic reticulum from ethanolamine …
Contemporary lipidomic analytics: opportunities and pitfalls
Recent advances in analytical techniques have greatly enhanced the depth of coverage,
however lipidomic studies are still restricted to analysing only a subset of known lipids …
however lipidomic studies are still restricted to analysing only a subset of known lipids …
Alkylglycerol: not abundant but promising functional lipid
HL Wang, CP Tan, Y Liu, YJ Xu - Trends in Food Science & Technology, 2024 - Elsevier
Background Alkylglycerols are a special class of functional ether lipids. In recent years,
these functional lipids have garnered significant attention due to their unique biological …
these functional lipids have garnered significant attention due to their unique biological …