A hierarchy of biomolecular proportional-integral-derivative feedback controllers for robust perfect adaptation and dynamic performance

M Filo, S Kumar, M Khammash - Nature communications, 2022 - nature.com
Abstract Proportional-Integral-Derivative (PID) feedback controllers are the most widely used
controllers in industry. Recently, the design of molecular PID-controllers has been identified …

Design of a synthetic integral feedback circuit: dynamic analysis and DNA implementation

C Briat, C Zechner, M Khammash - ACS synthetic biology, 2016 - ACS Publications
The design and implementation of regulation motifs ensuring robust perfect adaptation are
challenging problems in synthetic biology. Indeed, the design of high-yield robust metabolic …

Antithetic proportional-integral feedback for reduced variance and improved control performance of stochastic reaction networks

C Briat, A Gupta, M Khammash - Journal of The Royal …, 2018 - royalsocietypublishing.org
The ability of a cell to regulate and adapt its internal state in response to unpredictable
environmental changes is called homeostasis and this ability is crucial for the cell's survival …

A biology-inspired approach to the positive integral control of positive systems: The antithetic, exponential, and logistic integral controllers

C Briat - SIAM Journal on Applied Dynamical Systems, 2020 - SIAM
The integral control of positive systems using nonnegative control input is an important
problem arising in among others, biochemistry, epidemiology, and ecology. An immediate …

Low‐gain integral control for a class of discrete‐time Lur'e systems with applications to sampled‐data control

C Guiver, R Rebarber, S Townley - International Journal of …, 2023 - Wiley Online Library
We study low‐gain (P) roportional (I) ntegral control of multivariate discrete‐time, forced
Lur'e systems to solve the output‐tracking problem for constant reference signals. We …

Simple adaptive control for positive linear systems with applications to pest management

C Guiver, C Edholm, Y **, M Mueller, J Powell… - SIAM Journal on Applied …, 2016 - SIAM
Pest management is vitally important for modern arable farming, but models for pest species
are often highly uncertain. In the context of pest management, control actions are naturally …

Variance reduction for antithetic integral control of stochastic reaction networks

C Briat, A Gupta, M Khammash - arxiv preprint arxiv:1711.08291, 2017 - arxiv.org
The antithetic integral feedback motif recently introduced in Briat, Gupta & Khammash (Cell
Systems, 2017) is known to ensure robust perfect adaptation for the mean dynamics of a …

In-silico proportional-integral moment control of stochastic gene expression

C Briat, M Khammash - IEEE Transactions on Automatic …, 2020 - ieeexplore.ieee.org
In-silico control of complex stochastic biological systems is a promising area of
cybergenetics, which provides enabling theoretical and practical tools for the real-time …

[PDF][PDF] A class of simple biomolecular antithetic proportional-integral-derivative controllers

M Filo, M Khammash - bioRxiv, 2021 - scholar.archive.org
Abstract Proportional-Integral-Derivative (PID) feedback controllers have been the most
widely used controllers in the industry for almost a century. This is mainly due to their …

Design of control algorithms for false information dissemination in smart city social media based on symmetric triangle interval

K **g - Soft Computing, 2023 - Springer
The development of smart cities cannot be separated from information technology. In recent
years, with the development of urban modernization and intelligence in China, information …