BACKGROUND Childhood cancer incidence and survivorship are both on the rise.
However, many lifesaving treatments threaten the prepubertal testis. Cryopreservation of …

The germline cells are essential for the propagation of human beings, thus essential for the
survival of mankind. The germline stem cells, as a unique cell type, generate various states …

Spermatogonial stem cells (SSCs) are a group of adult stem cells in the testis that serve as
the foundation of continuous spermatogenesis and male fertility. SSCs are capable of self …

Male infertility is a major health problem affecting about 8–12% of couples worldwide.
Spermatogenesis starts in the early fetus and completes after puberty, passing through …

Spermatogenesis holds considerable promise for human-assisted reproduction and
livestock breeding based on stem cells. It occurs in seminiferous tubules within the testis …

Since their initial description by Enrico Sertoli in 1865, Sertoli cells have continued to
enchant testis biologists. Testis size and germ cell carrying capacity are intimately tied to …

Fertility preservation via biobanking of testicular tissue retrieved from testicular biopsies is
now generally recommended for boys who need to undergo gonadotoxic treatment prior to …

Fertility restoration using autologous testicular tissue transplantation is relevant for infertile
men surviving from childhood cancer and, possibly, in men with absent or incomplete …

Background Cancer treatment of prepubertal patients impacts future fertility due to the
abolition of spermatogonial stem cells (SSCs). In macaques, spermatogenesis could be …

Low back pain (LBP) caused by intervertebral disc degeneration (IVDD) is accredited to the
release of inflammatory cytokines followed by biomechanical and structural deterioration. In …