Platelet concentrate (PC) transfusions are a lifesaving adjunct to control and prevent
bleeding in cancer, hematologic, surgical, and trauma patients. Platelet concentrate …

Biochemical investigations on the regulatory mechanisms of red blood cell (RBC) and
platelet (PLT) metabolism have fostered a century of advances in the field of transfusion …

The increasing availability of metabolomics data necessitates novel methods for deeper
data analysis and interpretation. We present a flux balance analysis method that allows for …

Alzheimer's disease (AD) is the most common cause of adult dementia. Yet the complete set
of molecular changes accompanying this inexorable, neurodegenerative disease remains …

Metabolomic investigations of packed red blood cells (RBCs) stored under refrigerated
conditions in saline adenine glucose mannitol (SAGM) additives have revealed the …

BACKGROUND There has been interest in determining whether older red blood cell (RBC)
units have negative clinical effects. Numerous observational studies have shown that older …

Platelets transfusion is a safe process, but during or after the process, the recipient may
experience an adverse reaction and occasionally a serious adverse reaction (SAR). In this …

When platelet concentrates (PCs) were first introduced in the 1960s as a blood component
therapy, they were stored in the cold. As platelet transfusion became more important for the …

Background Plasma and serum are the most widely used matrices in clinical studies.
However, some variability in absolute concentrations of metabolites are likely to be …

Background Refrigeration, or cold‐storage, of platelets may be beneficial to extend the
limited shelf‐life of conventionally stored platelets and support transfusion protocols in rural …