Microbial and animal rhodopsins: structures, functions, and molecular mechanisms
Organisms of all domains of life use photoreceptor proteins to sense and respond to light.
The light-sensitivity of photoreceptor proteins arises from bound chromophores such as …
The light-sensitivity of photoreceptor proteins arises from bound chromophores such as …
Membrane protein structure and dynamics from NMR spectroscopy
We review the current state of membrane protein structure determination using solid-state
nuclear magnetic resonance (NMR) spectroscopy. Multidimensional magic-angle-spinning …
nuclear magnetic resonance (NMR) spectroscopy. Multidimensional magic-angle-spinning …
Crystal structure of metarhodopsin II
HW Choe, YJ Kim, JH Park, T Morizumi, EF Pai… - Nature, 2011 - nature.com
G-protein-coupled receptors (GPCRs) are seven transmembrane helix (TM) proteins that
transduce signals into living cells by binding extracellular ligands and coupling to …
transduce signals into living cells by binding extracellular ligands and coupling to …
Curvature and hydrophobic forces drive oligomerization and modulate activity of rhodopsin in membranes
G protein-coupled receptors (GPCRs) are essential components of cellular signaling
pathways. They are the targets of many current pharmaceuticals and are postulated to …
pathways. They are the targets of many current pharmaceuticals and are postulated to …
Concepts and methods of solid-state NMR spectroscopy applied to biomembranes
TR Molugu, S Lee, MF Brown - Chemical reviews, 2017 - ACS Publications
Concepts of solid-state NMR spectroscopy and applications to fluid membranes are
reviewed in this paper. Membrane lipids with 2H-labeled acyl chains or polar head groups …
reviewed in this paper. Membrane lipids with 2H-labeled acyl chains or polar head groups …
Photoreceptors take charge: emerging principles for light sensing
The first stage in biological signaling is based on changes in the functional state of a
receptor protein triggered by interaction of the receptor with its ligand (s). The light-triggered …
receptor protein triggered by interaction of the receptor with its ligand (s). The light-triggered …
250 GHz CW gyrotron oscillator for dynamic nuclear polarization in biological solid state NMR
In this paper, we describe a 250GHz gyrotron oscillator, a critical component of an integrated
system for magic angle spinning (MAS) dynamic nuclear polarization (DNP) experiments at …
system for magic angle spinning (MAS) dynamic nuclear polarization (DNP) experiments at …
Two protonation switches control rhodopsin activation in membranes
M Mahalingam, K Martínez-Mayorga… - Proceedings of the …, 2008 - National Acad Sciences
Activation of the G protein-coupled receptor (GPCR) rhodopsin is initiated by light-induced
isomerization of the retinal ligand, which triggers 2 protonation switches in the …
isomerization of the retinal ligand, which triggers 2 protonation switches in the …
[HTML][HTML] Recent progress in the study of G protein-coupled receptors with molecular dynamics computer simulations
A Grossfield - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2011 - Elsevier
G protein-coupled receptors (GPCRs) are a large, biomedically important family of proteins,
and the recent explosion of new high-resolution structural information about them has …
and the recent explosion of new high-resolution structural information about them has …
Mechanism of signal propagation upon retinal isomerization: insights from molecular dynamics simulations of rhodopsin restrained by normal modes
As one of the best studied members of the pharmaceutically relevant family of G-protein-
coupled receptors, rhodopsin serves as a prototype for understanding the mechanism of G …
coupled receptors, rhodopsin serves as a prototype for understanding the mechanism of G …