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Understanding neuroimmune interactions in disorders of gut–brain interaction: from functional to immune-mediated disorders
Functional gastrointestinal disorders—recently renamed into disorders of gut–brain
interaction—such as irritable bowel syndrome and functional dyspepsia are highly prevalent …
interaction—such as irritable bowel syndrome and functional dyspepsia are highly prevalent …
TRPA1 as a therapeutic target for nociceptive pain
D Souza Monteiro de Araujo, R Nassini… - Expert opinion on …, 2020 - Taylor & Francis
Introduction Chronic pain affects approximatively 30–50% of the population globally.
Pathologies such as migraine, diabetic neuropathy, nerve injury and treatment with …
Pathologies such as migraine, diabetic neuropathy, nerve injury and treatment with …
Irritable bowel syndrome: treatment based on pathophysiology and biomarkers
Objective To appraise the evidence that pathophysiological mechanisms and individualised
treatment directed at those mechanisms provide an alternative approach to the treatment of …
treatment directed at those mechanisms provide an alternative approach to the treatment of …
The gut microbiome in disorders of gut–brain interaction
Functional gastrointestinal disorders (FGIDs), chronic disorders characterized by either
abdominal pain, altered intestinal motility, or their combination, have a worldwide …
abdominal pain, altered intestinal motility, or their combination, have a worldwide …
“Sentinel or accomplice”: gut microbiota and microglia crosstalk in disorders of gut–brain interaction
Abnormal brain–gut interaction is considered the core pathological mechanism behind the
disorders of gut–brain interaction (DGBI), in which the intestinal microbiota plays an …
disorders of gut–brain interaction (DGBI), in which the intestinal microbiota plays an …
Mast cell activation syndrome: a primer for the gastroenterologist
Mast cell activation syndrome is thought to be a common, yet under-recognized, chronic
multi-system disorder caused by inappropriate mast cell activation. Gastrointestinal …
multi-system disorder caused by inappropriate mast cell activation. Gastrointestinal …
Irritable bowel syndrome: When food is a pain in the gut
H Hussein, S Van Remoortel… - Immunological …, 2024 - Wiley Online Library
Irritable bowel syndrome (IBS) is a chronic gastrointestinal condition associated with altered
bowel habits and recurrent abdominal pain, often triggered by food intake. Current …
bowel habits and recurrent abdominal pain, often triggered by food intake. Current …
[HTML][HTML] Intestinal neuro-immune interactions: focus on macrophages, mast cells and innate lymphoid cells
Highlights•Neuro-immune crosstalk occurs in distinct anatomical niches in the
intestine.•Neuro-immune cell niches maintain gut homeostasis and modulate …
intestine.•Neuro-immune cell niches maintain gut homeostasis and modulate …
Endocannabinoids regulate enteric neuron–glia networks and visceral hypersensitivity following inflammation through a glial‐dependent mechanism
Acute gastrointestinal (GI) inflammation induces neuroplasticity that produces long‐lasting
changes in gut motor function and pain. The endocannabinoid system is an attractive target …
changes in gut motor function and pain. The endocannabinoid system is an attractive target …
Histamine-dependent interactions between mast cells, glia, and neurons are altered following early-life adversity in mice and humans
Early-life adversity contributes to the development of functional bowel disorders later in life
through unresolved mechanisms. Here, we tested the hypothesis that early-life adversity …
through unresolved mechanisms. Here, we tested the hypothesis that early-life adversity …