Basic mechanisms of diabetic heart disease

RH Ritchie, ED Abel - Circulation research, 2020 - ahajournals.org
Diabetes mellitus predisposes affected individuals to a significant spectrum of
cardiovascular complications, one of the most debilitating in terms of prognosis is heart …

Cellular and molecular differences between HFpEF and HFrEF: a step ahead in an improved pathological understanding

SJ Simmonds, I Cuijpers, S Heymans, EAV Jones - Cells, 2020 - mdpi.com
Heart failure (HF) is the most rapidly growing cardiovascular health burden worldwide. HF
can be classified into three groups based on the percentage of the ejection fraction (EF) …

Microvascular dysfunction in diabetes mellitus and cardiometabolic disease

WB Horton, EJ Barrett - Endocrine reviews, 2021 - academic.oup.com
This review takes an inclusive approach to microvascular dysfunction in diabetes mellitus
and cardiometabolic disease. In virtually every organ, dynamic interactions between the …

[HTML][HTML] Impact of SGLT2 inhibitors on heart failure: from pathophysiology to clinical effects

G Palmiero, A Cesaro, E Vetrano, PC Pafundi… - International Journal of …, 2021 - mdpi.com
Heart failure (HF) affects up to over 20% of patients with type 2 diabetes (T2DM), even more
in the elderly. Although, in T2DM, both hyperglycemia and the proinflammatory status …

Diabetic microvascular disease in non-classical beds: the hidden impact beyond the retina, the kidney, and the peripheral nerves

D Mauricio, M Gratacòs, J Franch-Nadal - Cardiovascular Diabetology, 2023 - Springer
Diabetes microangiopathy, a hallmark complication of diabetes, is characterised by
structural and functional abnormalities within the intricate network of microvessels beyond …

[HTML][HTML] Coronary microvascular dysfunction in diabetes mellitus: pathogenetic mechanisms and potential therapeutic options

T Salvatore, R Galiero, A Caturano, E Vetrano… - Biomedicines, 2022 - mdpi.com
Diabetic patients are frequently affected by coronary microvascular dysfunction (CMD), a
condition consisting of a combination of altered vasomotion and long-term structural change …

Hypomagnesemia and cardiovascular risk in type 2 diabetes

LJ Oost, CJ Tack, JHF de Baaij - Endocrine Reviews, 2023 - academic.oup.com
Hypomagnesemia is 10-fold more common in individuals with type 2 diabetes (T2D) than in
the healthy population. Factors that are involved in this high prevalence are low Mg2+ …

Regional adiposity and heart failure with preserved ejection fraction

VN Rao, M Fudim, RJ Mentz… - European journal of …, 2020 - Wiley Online Library
The role of obesity in the pathogenesis of heart failure (HF), and in particular HF with
preserved ejection fraction (HFpEF), has drawn significant attention in recent years. The …

Sex-specific associations of cardiovascular risk factors and biomarkers with incident heart failure

N Suthahar, ES Lau, MJ Blaha, SM Paniagua… - Journal of the American …, 2020 - jacc.org
Background Whether cardiovascular (CV) disease risk factors and biomarkers associate
differentially with heart failure (HF) risk in men and women is unclear. Objectives The …

Serum magnesium is inversely associated with heart failure, atrial fibrillation, and microvascular complications in type 2 diabetes

LJ Oost, AAWA van der Heijden, EA Vermeulen… - Diabetes …, 2021 - diabetesjournals.org
OBJECTIVE We investigated whether serum magnesium (Mg2+) was prospectively
associated with macro-or microvascular complications and mediated by glycemic control …