The rapid development of drug nanocarriers has benefited from the surface hydrophilic
polymers of particles, which has improved the pharmacokinetics of the drugs. Polyethylene …

In vertebrates, transferrin (Tf) safely delivers iron through circulation to cells. Tf-bound iron is
incorporated through Tf receptor (TfR) 1-mediated endocytosis. TfR1 can mediate cellular …

Abstract Development of enzyme mimics for the scavenging of excessive mitochondrial
superoxide (O2•−) can serve as an effective strategy in the treatment of many diseases …

Nanoparticle size plays a central role in determining material properties and performance in
biomedical applications. A wide variety of functional nanomaterials and nano-bioconjugates …

The impermeable barrier of solid tumors due to the complexity of their components limits the
treatment effect of nanomedicine and hinders its clinical translation. Several methods are …

Orally administrable anticancer nanomedicines are highly desirable due to their easy and
repeatable administration, but are not yet feasible because the current nanomedicine cannot …

Drug delivery by nanocarriers (NCs) has long been stymied by dominant liver uptake and
limited target organ deposition, even when NCs are targeted using affinity moieties. Here we …

An abundant number of nanomaterials have been discovered to possess enzyme‐like
catalytic activity, termed nanozymes. It is identified that a variety of internal and external …

The central dogma that nanoparticle delivery to tumours requires enhanced leakiness of
vasculatures is a topic of debate. To address this, we propose a single-vessel quantitative …

The ability of cells to sense external mechanical cues is essential for their adaptation to the
surrounding microenvironment. However, how nanoparticle mechanical properties affect cell …