Summary The interleukin (IL)‐1 family of cytokines is currently comprised of 11 members
that have pleiotropic functions in inflammation and cancer. IL‐1α and IL‐1β were the first …

Src is a non-receptor tyrosine kinase that is deregulated in many types of cancer. Decades
of research have revealed the crucial role of Src in many aspects of tumor development …

Inhibitory leukocyte immunoglobulin-like receptors (LILRBs 1-5) transduce signals via
intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that recruit protein …

Neutrophil-mediated skin diseases, originally named neutrophilic dermatoses (NDs), are a
group of conditions due to an altered neutrophil recruitment and activation, characterized by …

Chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) are 2 well-defined
entities that diverge in their basic pathogenic mechanisms and clinical evolution but they …

Biologists and clinicians agree that the B-cell receptor influences the behavior of chronic
lymphocytic leukemia, and promising new drugs are aimed at receptor-associated kinases …

There is increasing interest in the chronic lymphocytic leukemia (CLL) microenvironment
and the mechanisms that may promote CLL cell survival and proliferation. A role for T helper …

Since its discovery, over 30 years ago, CD5 has been used as a marker to identify T cells,
B1-a cells, and B cell chronic lymphocytic leukemia cells. Throughout the years, many …

Conventional strategies are not particularly successful in the treatment of leukaemia, and
identification of signalling pathways crucial to the activity of leukaemia stem cells will provide …

CD5 is a pan-T-cell surface marker and is rarely expressed in diffuse large B-cell lymphoma
(DLBCL). Large-scale studies of de novo CD5+ DLBCL are lacking in Western countries. In …