Cathepsin B (CatB), a cysteine protease, is primarily localized within subcellular endosomal
and lysosomal compartments. It is involved in the turnover of intracellular and extracellular …

Most cancer-related deaths are a result of metastasis, and thus the importance of this
process as a target of therapy cannot be understated. By asking 'how can we effectively treat …

The extracellular matrix (ECM) is increasingly recognized as an important regulator in breast
cancer. ECM in breast cancer development features numerous changes in composition and …

Proteases, including intracellular proteases, play roles at many different stages of malignant
progression. Our focus here is cathepsin B, a lysosomal cysteine cathepsin. High levels of …

Tumor cells metastasize to distant organs through genetic and epigenetic alterations,
including changes in microRNA (miR) expression. Here we find miR-22 triggers epithelial …

Lysosomes are membrane‐bound intracellular organelles that receive macromolecules
delivered by endocytosis, phagocytosis, and autophagy for degradation and recycling. Over …

Cysteine proteases continue to provide validated targets for treatment of human diseases. In
neurodegenerative disorders, multiple cysteine proteases provide targets for enzyme …

In eukaryotic cells, lysosomes are digestive centers where biological macromolecules are
degraded by phagocytosis and autophagy, thereby maintaining cellular self-renewal …

The extracellular matrix (ECM) is composed of highly variable and dynamic components that
regulate cell behavior. The protein composition and physical properties of the ECM govern …

Since the discovery of the key role of cathepsin K in bone resorption, cysteine cathepsins
have been investigated by pharmaceutical companies as drug targets. The first clinical …