Click Reaction Inspired Enzyme Inhibitors in Diabetes Care: An Update in the Field of Chronic Metabolic Disorder

D Mudgal, N Yadav, GK Srivastava… - Current …, 2025 - benthamdirect.com
Diabetes is a chronic metabolic disorder that impacts all age groups and affects a large
population worldwide. Humans receive glucose from almost every food source, and after …

Recent Progress in the Synthesis and Biological Assessment of Benzimidazole-1, 2, 3-Triazole Hybrids

DK Singh, H Iqbal, MA Ansari - Current Organic Chemistry, 2024 - benthamdirect.com
In recent times, many research groups have focused their attention on nitrogencontaining
heterocyclic compounds with the aim of gaining a deeper understanding of their biological …

Clickable Probes for Pathogen Proteasomes: Synthesis and Applications

LJ Liu, B Lucero, C Manriquez-Rodriguez… - ACS …, 2024 - ACS Publications
The 20S proteasome is a multimeric protease complex that is essential for proteostasis in
the cell. Small molecule proteasome inhibitors are approved drugs for various cancers and …

Synthesis and Characterization of Click Chemical Probes for Single-Cell Resolution Detection of Epichaperomes in Neurodegenerative Disorders

S Bay, CS Digwal, AM Rodilla Martín, S Sharma… - Biomedicines, 2024 - mdpi.com
Neurodegenerative disorders, including Alzheimer's disease (AD) and Parkinson's disease
(PD), represent debilitating conditions with complex, poorly understood pathologies …

Novel hybrid motifs of 2-(2-pyridinyl)-1H-benzo [d] imidazole-1, 2, 3-triazole: Synthesis, anticancer assessment, and in silico study

SD Al-Qahtani, GM Al-Senani - Journal of Molecular Structure, 2024 - Elsevier
Abstract A new category of 1, 2, 3-triazole-pyridine-benzo [d] imidazole hybrids (12–21)
were prepared by a Cu (I)-catalyzed Alkyne-Azide Cyclic-addition (CuAAC) procedure …

Calcium (II)‐Catalyzed Synthesis of Sulfoximinocyclopentenones

X Chen, C Bour, E Kolodziej, R Guillot… - Advanced Synthesis …, 2025 - Wiley Online Library
Abstract A series of 4‐sulfoximinocyclopent‐2‐en‐1‐ones was prepared in 35 to 99% yield
through a calcium (II)‐catalyzed aza‐Piancatelli reaction, including in enantioenriched form …

Solid Phase Synthesis and TAR RNA-Binding Activity of Nucleopeptides Containing Nucleobases Linked to the Side Chains via 1, 4-Linked-1, 2, 3-triazole

P Mucha, M Pieszko, I Bylińska, W Wiczk, J Ruczyński… - Biomedicines, 2024 - mdpi.com
Nucleopeptides (NPs) represent synthetic polymers created by attaching nucleobases to the
side chains of amino acid residues within peptides. These compounds amalgamate the …

1H, 1, 2, 3-Triazole Tethered imidazole-Isatin Conjugates: Synthesis, DFT and Optical properties

R Rajapriya, MS Dangate - Journal of Molecular Structure, 2024 - Elsevier
Novel functional materials, namely TPI-TAZ-ISA, NADPI-TAZ-ISA, ADPI-TAZ-ISA, and
DMAPDPI-TAZ-ISA, were synthesized utilizing click chemical reactions and subjected to …

[PDF][PDF] RED-LIGHT PHOTOSWITCHABLE INDIGO-CROSSLINKED GELS

S Rantamäki - 2024 - trepo.tuni.fi
Responsive swellable, loosely crosslinked polymer networks, also known as gels, are part of
ongoing research aimed at develo** smart materials that can respond to environmental …

1h, 1, 2, 3-Triazole Tethered Imidazole-Isatin Conjugates: Synthesis, Dft and Optical Properties

MS Dangate, R Rajapriya - Dft and Optical Properties - papers.ssrn.com
Novel functional materials, namely TPI-TAZ-ISA, NADPI-TAZ-ISA, ADPI-TAZ-ISA, and
DMAPDPI-TAZ-ISA, were synthesized utilizing click chemical reactions and subjected to …