Organoids—cellular aggregates derived from stem or progenitor cells that recapitulate organ
function in miniature—are of growing interest in developmental biology and medicine …

Tumorigenesis is a complex and dynamic process, consisting of three stages: initiation,
progression, and metastasis. Tumors are encircled by extracellular matrix (ECM) and …

Simple Summary For the research and development of drug discovery, it is of prime
importance to construct the three-dimensional (3D) tissue models in vitro. To this end, the …

The tumor microenvironment plays a pivotal role in tumor initiation and progression by
creating a dynamic interaction with cancer cells. The tumor microenvironment consists of …

Cells have traditionally been viewed either as independently moving entities or as
somewhat static parts of tissues. However, it is now clear that in many cases, multiple cells …

Mesenchymal stem/stromal cells (MSCs) are multipotent cells involved in numerous
physiological events, including organogenesis, the maintenance of tissue homeostasis …

The extracellular matrix (ECM) establishes the basis for the cell's microenvironment
providing structural and mechanical support to cells and tissues, and regulating multiple cell …

Ovarian cancer (OC) is the fifth cancer death cause in women worldwide. The malignant
nature of this disease stems from its unique dissemination pattern. Epithelial-to …

Cancer is one of the leading causes of death globally according to the World Health
Organization. Although improved treatments and early diagnoses have reduced cancer …

Cancer cells are usually found to be softer than normal cells, but their stiffness changes
when they are in contact with different environments because of mechanosensitivity. For …