Molecular mechanisms of fragile X syndrome: a twenty-year perspective
MR Santoro, SM Bray, ST Warren - Annual Review of Pathology …, 2012 - annualreviews.org
Fragile X syndrome (FXS) is a common form of inherited intellectual disability and is one of
the leading known causes of autism. The mutation responsible for FXS is a large expansion …
the leading known causes of autism. The mutation responsible for FXS is a large expansion …
Disruption of RNA metabolism in neurological diseases and emerging therapeutic interventions
RNA binding proteins are critical to the maintenance of the transcriptome via controlled
regulation of RNA processing and transport. Alterations of these proteins impact multiple …
regulation of RNA processing and transport. Alterations of these proteins impact multiple …
[HTML][HTML] A mammalian microRNA expression atlas based on small RNA library sequencing
MicroRNAs (miRNAs) are small noncoding regulatory RNAs that reduce stability and/or
translation of fully or partially sequence-complementary target mRNAs. In order to identify …
translation of fully or partially sequence-complementary target mRNAs. In order to identify …
[HTML][HTML] Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132
MicroRNAs (miRNAs) are noncoding RNAs that suppress translation of specific mRNAs. The
miRNA machinery interacts with fragile X mental retardation protein (FMRP), which functions …
miRNA machinery interacts with fragile X mental retardation protein (FMRP), which functions …
Psychosis and autism as diametrical disorders of the social brain
B Crespi, C Badcock - Behavioral and brain sciences, 2008 - cambridge.org
Autistic-spectrum conditions and psychotic-spectrum conditions (mainly schizophrenia,
bipolar disorder, and major depression) represent two major suites of disorders of human …
bipolar disorder, and major depression) represent two major suites of disorders of human …
Existence of a microRNA pathway in anucleate platelets
P Landry, I Plante, DL Ouellet, MP Perron… - Nature structural & …, 2009 - nature.com
Platelets have a crucial role in the maintenance of hemostasis as well as in thrombosis and
vessel occlusion, which underlie stroke and acute coronary syndromes. Anucleate platelets …
vessel occlusion, which underlie stroke and acute coronary syndromes. Anucleate platelets …
MicroRNAs in disease and potential therapeutic applications
MicroRNAs (miRNAs) are 21–24 nucleotide (nt) duplex RNAs that are created from
precursor transcripts by subsequent processing steps mediated by members of the RNAseIII …
precursor transcripts by subsequent processing steps mediated by members of the RNAseIII …
The pathophysiology of fragile X (and what it teaches us about synapses)
Fragile X is the most common known inherited cause of intellectual disability and autism,
and it typically results from transcriptional silencing of FMR1 and loss of the encoded …
and it typically results from transcriptional silencing of FMR1 and loss of the encoded …
Let me count the ways: mechanisms of gene regulation by miRNAs and siRNAs
L Wu, JG Belasco - Molecular cell, 2008 - cell.com
The downregulation of gene expression by miRNAs and siRNAs is a complex process
involving both translational repression and accelerated mRNA turnover, each of which …
involving both translational repression and accelerated mRNA turnover, each of which …
[HTML][HTML] G-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptome
G-rich sequences in DNA and RNA have a propensity to fold into stable secondary
structures termed G-quadruplexes. G-quadruplex forming sequences are widespread …
structures termed G-quadruplexes. G-quadruplex forming sequences are widespread …