Genomic-scale prioritization of drug targets: the TDR Targets database
The increasing availability of genomic data for pathogens that cause tropical diseases has
created new opportunities for drug discovery and development. However, if the potential of …
created new opportunities for drug discovery and development. However, if the potential of …
Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence
Toxoplasma gondii is an obligate intracellular protozoan parasite that can infect most warm‐
blooded animals and cause severe and life‐threatening disease in develo** fetuses and …
blooded animals and cause severe and life‐threatening disease in develo** fetuses and …
[LLIBRE][B] Toxoplasma gondii: the model apicomplexan-perspectives and methods
LM Weiss - 2013 - books.google.com
This 2e of Toxoplasma gondii reflects the significant advances in the field in the last 5 years,
including new information on the genomics, epigenomics and proteomics of T. gondii as well …
including new information on the genomics, epigenomics and proteomics of T. gondii as well …
1H NMR-based Metabolomic Profiling in Mice Infected with Mycobacterium tuberculosis
JH Shin, JY Yang, BY Jeon, YJ Yoon… - Journal of proteome …, 2011 - ACS Publications
Tuberculosis (TB) is one of three major infectious diseases, and the control of TB is
becoming more difficult because of the emergence of multidrug-resistant and extensively …
becoming more difficult because of the emergence of multidrug-resistant and extensively …
Metabolic changes in Toxoplasma gondii-infected host cells measured by autofluorescence imaging
Toxoplasma gondii, the causative agent of toxoplasmosis, is an obligate intracellular
parasite that infects warm-blooded vertebrates across the world. In humans, seropositivity …
parasite that infects warm-blooded vertebrates across the world. In humans, seropositivity …
Host cell manipulation by the human pathogen Toxoplasma gondii
J Laliberte, VB Carruthers - Cellular and molecular life sciences, 2008 - Springer
Toxoplasma gondii is an obligate intracellular parasite that can infect virtually any nucleated
cell. During invasion Toxoplasma creates the parasitophorous vacuole, a subcellular …
cell. During invasion Toxoplasma creates the parasitophorous vacuole, a subcellular …
Purine and pyrimidine transport in pathogenic protozoa: from biology to therapy
Purine salvage is an essential function for all obligate parasitic protozoa studied to date and
most are also capable of efficient uptake of preformed pyrimidines. Much progress has been …
most are also capable of efficient uptake of preformed pyrimidines. Much progress has been …
Targeting purine and pyrimidine metabolism in human apicomplexan parasites
JE Hyde - Current drug targets, 2007 - ingentaconnect.com
Synthesis de novo, acquisition by salvage and interconversion of purines and pyrimidines
represent the fundamental requirements for their eventual assembly into nucleic acids as …
represent the fundamental requirements for their eventual assembly into nucleic acids as …
Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlap** gene families to attach, invade, and …
Abstract Background The apicomplexan parasite Toxoplasma gondii is cosmopolitan in
nature, largely as a result of its highly flexible life cycle. Felids are its only definitive hosts …
nature, largely as a result of its highly flexible life cycle. Felids are its only definitive hosts …
Macrophage nutriprive antimicrobial mechanisms
R Appelberg - Journal of leukocyte biology, 2006 - academic.oup.com
In addition to oxidative and antibiotic mechanisms of antimicrobial activity, macrophages are
able to deprive intracellular pathogens of required nutrients. Thus, microbial killing may not …
able to deprive intracellular pathogens of required nutrients. Thus, microbial killing may not …