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Exploiting the biogenesis of extracellular vesicles for bioengineering and therapeutic cargo loading
J Rädler, D Gupta, A Zickler, SEL Andaloussi - Molecular Therapy, 2023 - cell.com
Extracellular vesicles (EVs) are gaining increasing attention for diagnostic and therapeutic
applications in various diseases. These natural nanoparticles benefit from favorable safety …
applications in various diseases. These natural nanoparticles benefit from favorable safety …
LNCcation: lncRNA localization and function
MC Bridges, AC Daulagala, A Kourtidis - Journal of Cell Biology, 2021 - rupress.org
Subcellular localization of RNAs has gained attention in recent years as a prevalent
phenomenon that influences numerous cellular processes. This is also evident for the large …
phenomenon that influences numerous cellular processes. This is also evident for the large …
RNA delivery by extracellular vesicles in mammalian cells and its applications
The term 'extracellular vesicles' refers to a heterogeneous population of vesicular bodies of
cellular origin that derive either from the endosomal compartment (exosomes) or as a result …
cellular origin that derive either from the endosomal compartment (exosomes) or as a result …
Molecular landscape of LncRNAs in prostate cancer: a focus on pathways and therapeutic targets for intervention
S Mirzaei, MDA Paskeh, E Okina, MH Gholami… - Journal of Experimental …, 2022 - Springer
Background One of the most malignant tumors in men is prostate cancer that is still incurable
due to its heterogenous and progressive natures. Genetic and epigenetic changes play …
due to its heterogenous and progressive natures. Genetic and epigenetic changes play …
Regulation of microRNA function in animals
LFR Gebert, IJ MacRae - Nature reviews Molecular cell biology, 2019 - nature.com
Since their serendipitous discovery in nematodes, microRNAs (miRNAs) have emerged as
key regulators of biological processes in animals. These small RNAs form complex networks …
key regulators of biological processes in animals. These small RNAs form complex networks …
RNA packaging into extracellular vesicles: An orchestra of RNA‐binding proteins?
Extracellular vesicles (EVs) are heterogeneous membranous particles released from the
cells through different biogenetic and secretory mechanisms. We now conceive EVs as …
cells through different biogenetic and secretory mechanisms. We now conceive EVs as …
Cytoplasmic functions of long noncoding RNAs
Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides found
throughout the cell that lack protein‐coding function. Their functions are closely linked to …
throughout the cell that lack protein‐coding function. Their functions are closely linked to …
Emerging role of exosome-derived long non-coding RNAs in tumor microenvironment
Z Sun, S Yang, Q Zhou, G Wang, J Song, Z Li, Z Zhang… - Molecular cancer, 2018 - Springer
Exosomes are extracellular vesicles released by many cell types and have been attributed
for their roles in many diseases including cancer. Exosomes secreted by tumor cells and …
for their roles in many diseases including cancer. Exosomes secreted by tumor cells and …
Global positioning system: understanding long noncoding RNAs through subcellular localization
J Carlevaro-Fita, R Johnson - Molecular cell, 2019 - cell.com
The localization of long noncoding RNAs (lncRNAs) within the cell is the primary
determinant of their molecular functions. LncRNAs are often thought of as chromatin …
determinant of their molecular functions. LncRNAs are often thought of as chromatin …
Exosome biogenesis, secretion and function of exosomal miRNAs in skeletal muscle myogenesis
B Yue, H Yang, J Wang, W Ru, J Wu, Y Huang… - Cell …, 2020 - Wiley Online Library
Exosomes are membrane‐bound extracellular vesicles that are produced in the endosomal
compartment of most mammalian cell types and then released. Exosomes are effective …
compartment of most mammalian cell types and then released. Exosomes are effective …