[HTML][HTML] Navigating the landscape of RNA delivery systems in cardiovascular disease therapeutics

P Gil-Cabrerizo, T Simon-Yarza, E Garbayo… - Advanced Drug Delivery …, 2024 - Elsevier
Cardiovascular diseases (CVDs) stand as the leading cause of death worldwide, posing a
significant global health challenge. Consequently, the development of innovative …

Recent advances in therapeutic engineered extracellular vesicles

C Yao, H Zhang, C Wang - Nanoscale, 2024 - pubs.rsc.org
Extracellular vesicles (EVs) are natural particles secreted by living cells, which hold
significant potential for various therapeutic applications. Native EVs have specific …

Astrocyte-derived extracellular vesicles for ischemic stroke: therapeutic potential and prospective

X Wang, A Li, H Fan, Y Li, N Yang… - Aging and Disease, 2024 - pmc.ncbi.nlm.nih.gov
Stroke is a leading cause of death and disability in the world. Astrocytes are special glial
cells within the central nervous system and play important roles in mediating …

Harnessing exosomes for advanced osteoarthritis therapy

A Selvadoss, HM Baby, H Zhang, A Bajpayee - Nanoscale, 2024 - pubs.rsc.org
Exosomes are nanosized, lipid membrane vesicles secreted by cells, facilitating intercellular
communication by transferring their cargo from parent to recipient cells. This capability …

Extracellular vesicles: Illuminating Renal pathophysiology and therapeutic frontiers

L Shi, H Zeng, Z An, W Chen, Y Shan, C Ji… - European Journal of …, 2024 - Elsevier
Extracellular vesicles (EVs) are minute sacs released by cells into the extracellular milieu,
harboring an array of biomolecules including proteins, nucleic acids, and lipids. Notably, a …

Chondroitin sulfate-tocopherol succinate modified exosomes for targeted drug delivery to CD44-positive cancer cells

AH Mohammadi, F Bagheri, K Baghaei - International Journal of Biological …, 2024 - Elsevier
Exosomes (Exos), natural nanovesicles released by various cell types, show potential as an
effective drug delivery platform due to their intrinsic role as transporters of biomolecules …

A versatile engineered extracellular vesicle platform simultaneously targeting and eliminating senescent stromal cells and tumor cells to promote tumor regression

L Gong, Z Chen, K Feng, L Luo, J Zhang… - Journal of …, 2024 - Springer
Chemotherapy is an important therapeutic approach for malignant tumors for it triggers
apoptosis of cancer cells. However, chemotherapy also induces senescence of stromal cells …

Applications of plant‐derived extracellular vesicles in medicine

Y Zhu, J Zhao, H Ding, M Qiu, L Xue, D Ge, G Wen… - MedComm, 2024 - Wiley Online Library
Plant‐derived extracellular vesicles (EVs) are promising therapeutic agents owing to their
natural abundance, accessibility, and unique biological properties. This review provides a …

Novel insights into the role of immunomodulatory extracellular vesicles in the pathogenesis of liver fibrosis

J Li, Y Yuan, Q Fu, M Chen, H Liang, X Chen… - Biomarker …, 2024 - Springer
Liver fibrosis, a chronic and long-term disease, can develop into hepatocellular carcinoma
(HCC) and ultimately lead to liver failure. Early diagnosis and effective treatment still face …

Extracellular vesicles as drug delivery systems in therapeutics: current strategies and future challenges

X Lu, S Fan, M Cao, D Liu, K Xuan, A Liu - Journal of Pharmaceutical …, 2024 - Springer
Abstract Background Extracellular vesicles (EVs), which are nanometer-sized vesicles
enclosed by lipid membranes, are secreted by most cells and contain lipids, proteins, and …