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[HTML][HTML] Toxicity of glutathione-binding metals: a review of targets and mechanisms
Mercury, cadmium, arsenic and lead are among priority metals for toxicological studies due
to the frequent human exposure and to the significant burden of disease following acute and …
to the frequent human exposure and to the significant burden of disease following acute and …
[HTML][HTML] Overview of structurally homologous flavoprotein oxidoreductases containing the low Mr thioredoxin reductase-like fold–A functionally diverse group
M Hammerstad, HP Hersleth - Archives of biochemistry and biophysics, 2021 - Elsevier
Structural studies show that enzymes have a limited number of unique folds, although
structurally related enzymes have evolved to perform a large variety of functions. In this …
structurally related enzymes have evolved to perform a large variety of functions. In this …
The mercury resistance operon: from an origin in a geothermal environment to an efficient detoxification machine
Mercuric mercury (Hg [II]) is a highly toxic and mobile element that is likely to have had a
pronounced and adverse effect on biology since Earth's oxygenation∼ 2.4 billion years ago …
pronounced and adverse effect on biology since Earth's oxygenation∼ 2.4 billion years ago …
Expanded Diversity and Phylogeny of mer Genes Broadens Mercury Resistance Paradigms and Reveals an Origin for MerA Among Thermophilic Archaea
Mercury (Hg) is a highly toxic element due to its high affinity for protein sulfhydryl groups,
which upon binding, can destabilize protein structure and decrease enzyme activity …
which upon binding, can destabilize protein structure and decrease enzyme activity …
Mass dependent stable isotope fractionation of mercury during mer mediated microbial degradation of monomethylmercury
Controlling bioaccumulation of toxic monomethylmercury (MMHg) in aquatic food chains
requires differentiation between biotic and abiotic pathways that lead to its production and …
requires differentiation between biotic and abiotic pathways that lead to its production and …
Arsinothricin Biosynthesis Involving a Radical SAM Enzyme for Noncanonical SAM Cleavage and C–As Bond Formation
Y Yao, J He, F Chen, M Dong - Journal of the American Chemical …, 2024 - ACS Publications
Arsinothricin is a potent antibiotic secreted by soil bacteria. The biosynthesis of arsinothricin
was proposed to involve a C–As bond formation between trivalent As and the 3-amino-3 …
was proposed to involve a C–As bond formation between trivalent As and the 3-amino-3 …
A thermophilic bacterial origin and subsequent constraints by redox, light and salinity on the evolution of the microbial mercuric reductase
Mercuric reductase (MerA) is central to the mercury (Hg) resistance (mer) system, catalyzing
the reduction of ionic Hg to volatile Hg (0). A total of 213 merA homologues were identified in …
the reduction of ionic Hg to volatile Hg (0). A total of 213 merA homologues were identified in …
Building on a theme: The redox hierarchy of pyridine nucleotide-disulfide oxidoreductases
Flavin disulfide reductases (FDRs) are FAD-dependent enzymes that transmit electrons from
NAD (P) H to reduce specific oxidant substrate disulfides. These enzymes have been …
NAD (P) H to reduce specific oxidant substrate disulfides. These enzymes have been …
Horizontal gene transfer of the Mer operon is associated with large effects on the transcriptome and increased tolerance to mercury in nitrogen-fixing bacteria
Abstract Background Mercury (Hg) is highly toxic and has the potential to cause severe
health problems for humans and foraging animals when transported into edible plant parts …
health problems for humans and foraging animals when transported into edible plant parts …
Microbial stable isotope fractionation of mercury: A synthesis of present understanding and future directions
Mercury (Hg) is a trace metal with potentially serious public health consequences, especially
when its neurotoxic form, monomethylmercury (MMHg), accumulates in aquatic and …
when its neurotoxic form, monomethylmercury (MMHg), accumulates in aquatic and …