Neutrophils are main players in the effector phase of the host defense against micro-
organisms and have a major role in the innate immune response. Neutrophils show …

Peroxisome proliferator-activated receptor γ (PPARγ) is a widely expressed ligand-
modulated transcription factor that governs the expression of genes involved in …

Bacterial infection and excessive inflammation following abdominal injury can cause life‐
threatening complications that lead to multiple organ failure and death. Removing bacteria …

Chronic wounds are a silent epidemic threatening the lives of many people worldwide. They
are associated with social, health care and economic burdens and can lead to death if left …

Traumatic brain injury (TBI) is a leading cause of death in young adults and a risk factor for
acquired epilepsy. Severe TBI, after a period of time, causes numerous neuropsychiatric and …

Extracellular DNA‐binding proteins such as histones are danger‐associated molecular
pattern released by the injured tissues in trauma and sepsis settings, which trigger host …

Despite the rapid development of immunotherapy, low response rates, poor therapeutic
outcomes, and severe side effects still limit its implementation, making the augmentation of …

Autoinflammatory syndromes are a group of disorders characterized by recurring episodes
of inflammation as a result of specific defects in the innate immune system. Patients with …

BACKGROUND Frailty is a geriatric syndrome characterized by decreased physiological
reserves, increased inflammation, and decreased anabolic-endocrine response. The …

Background: Trauma is still a major cause of mortality in people< 50 years of age.
Biomarkers are needed to estimate the severity of the condition and the patient outcome …