Abstract The hormone melatonin (5-methoxy-N-acetyltryptamine) is synthesized primarily in
the pineal gland and retina, and in several peripheral tissues and organs. In the circulation …

Circadian rhythm sleep disorders (CRSDs), whether chronic or transient, affect a broad
range of individuals, including many elderly, those with severe visual impairments, shift …

Numerous physiological functions of the pineal gland hormone melatonin are mediated via
activation of two G-protein-coupled receptors, MT1 and MT2. The melatonergic drugs on the …

Depression, particularly unipolar depression, has often been linked to circadian (ie
approximately 24-h) rhythm abnormalities. The observation that many diverse rhythms are …

The indole nucleus is a prominent structural motif found in numerous natural products and
synthetic compounds with important biological activities, and thus considerable attention has …

In this review we summarized the actual clinical data for a cardioprotective therapeutic role
of melatonin, listed melatonin and its agonists in different stages of development, and …

The search for melatonin receptor agonists formed the main part of melatonin medicinal
chemistry programs for the last three decades. In this short review, we summarize the two …

A direct approach to 2-(aminomethyl) indoles by copper-catalyzed domino three-component
coupling− cyclization of 2-ethynylanilines with a secondary amine and aldehyde has been …

A novel series of melatonin receptor ligands, characterized by a N-(substituted-anilinoethyl)
amido scaffold, along with preliminary structure–activity relationships (SARs), is presented …

Molecular superposition models guided the design of novel melatonin receptor ligands
characterized by a 2-acylaminomethyltetrahydroquinoline scaffold. Starting from the …