DNA methylome, R-loop and clinical exome profiling of patients with sporadic amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by
the death of motor neurons, the aetiology of which is essentially unknown. Here, we present …
the death of motor neurons, the aetiology of which is essentially unknown. Here, we present …
DNA methylation in amyotrophic lateral sclerosis: where do we stand and what is next?
F Coppedè - Epigenomics, 2024 - Taylor & Francis
Genes involved in immune response, inflammation and metabolism are among those most
likely affected by changes in DNA methylation (DNAm) and expression levels in amyotrophic …
likely affected by changes in DNA methylation (DNAm) and expression levels in amyotrophic …
Sex-specific DNA methylation differences in Amyotrophic lateral sclerosis
Sex is an important covariate in all genetic and epigenetic research due to its role in the
incidence, progression and outcome of many phenotypic characteristics and human …
incidence, progression and outcome of many phenotypic characteristics and human …
The Promise of Epigenetic Editing for Treating Brain Disorders
Brain disorders, especially neurodegenerative diseases, affect millions of people worldwide.
There is no causal treatment available; therefore, there is an unmet clinical need for finding …
There is no causal treatment available; therefore, there is an unmet clinical need for finding …
Exploring DNA methylation profiles in the pathogenesis of human osteoporosis via whole-genome bisulfite sequencing
Y Zhang, Y Zhong, C Li, Y Zhang, S **ong, Q Li, H Guo… - 2024 - researchsquare.com
Background Osteoporosis is a prevalent bone metabolic disorder characterized by reduced
bone mass, disruption of bone microarchitecture, and increased bone fragility, leading to a …
bone mass, disruption of bone microarchitecture, and increased bone fragility, leading to a …