Non-motor features of Parkinson disease

AHV Schapira, KR Chaudhuri, P Jenner - Nature reviews neuroscience, 2017 - nature.com
Many of the motor symptoms of Parkinson disease (PD) can be preceded, sometimes for
several years, by non-motor symptoms that include hyposmia, sleep disorders, depression …

Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

JA Obeso, M Stamelou, CG Goetz, W Poewe… - Movement …, 2017 - Wiley Online Library
This article reviews and summarizes 200 years of Parkinson's disease. It comprises a
relevant history of Dr. James Parkinson's himself and what he described accurately and …

White matter changes in Parkinson's disease

K Yang, Z Wu, J Long, W Li, X Wang, N Hu… - npj Parkinson's …, 2023 - nature.com
Parkinson's disease (PD) is the second most common neurodegenerative disease after
Alzheimer's disease (AD). It is characterized by a progressive loss of dopaminergic neurons …

Magnetic resonance imaging for the diagnosis of Parkinson's disease

B Heim, F Krismer, R De Marzi, K Seppi - Journal of neural transmission, 2017 - Springer
The differential diagnosis of parkinsonian syndromes is considered one of the most
challenging in neurology and error rates in the clinical diagnosis can be high even at …

Depression and Parkinson's disease: current knowledge

L Marsh - Current neurology and neuroscience reports, 2013 - Springer
Depressive disturbances are common in patients with Parkinson's disease (PD) and
influence many other clinical aspects of the disease. In addition to causing inherent …

Depression in Parkinson disease—epidemiology, mechanisms and management

D Aarsland, S Påhlhagen, CG Ballard, U Ehrt… - Nature Reviews …, 2012 - nature.com
Depression occurs in around 35% of patients with Parkinson disease (PD) and is often
persistent. Symptoms of depression can be evident in individuals at the time of diagnosis …

[HTML][HTML] Baicalein alleviates depression-like behavior in rotenone-induced Parkinson's disease model in mice through activating the BDNF/TrkB/CREB pathway

X Zhao, D Kong, Q Zhou, G Wei, J Song, Y Liang… - Biomedicine & …, 2021 - Elsevier
Background Parkinson's disease (PD) is the second most prevalent neurodegenerative
disorder in the world. In addition to motor symptoms, a variety of non-motor symptoms …

The hidden sister of motor fluctuations in Parkinson's disease: A review on nonmotor fluctuations

R Martínez‐Fernández, E Schmitt… - Movement …, 2016 - Wiley Online Library
Only a few years after the introduction of levodopa, the first descriptions of motor fluctuations
and dyskinesia related to dopaminergic therapy appeared. In PD, attention turned to their …

Depression, anxiety, and apathy in Parkinson's disease: insights from neuroimaging studies

MC Wen, LL Chan, LCS Tan… - European journal of …, 2016 - Wiley Online Library
Depression, anxiety and apathy are common mood disturbances in Parkinson's disease
(PD) but their pathophysiology is unclear. Advanced neuroimaging has been increasingly …

Stress, depression and Parkinson's disease

AM Hemmerle, JP Herman, KB Seroogy - Experimental neurology, 2012 - Elsevier
In this review, we focus on the relationship among Parkinson's disease (PD), stress and
depression. Parkinson's disease patients have a high risk of develo** depression, and it is …