In the past decade, changes have occurred in the spectrum of multiple sclerosis courses.
The natural history of multiple sclerosis appears milder from the first sign of demyelinating …

Over the last decade, clinical registries have significantly contributed to the pool of evidence
that supports management decisions in patients with multiple sclerosis. Being the largest …

Background Group-based trajectory modelling (GBTM) is increasingly used to identify
subgroups of individuals with similar patterns. In this paper, we use simulated and real-life …

Abstract Background and Objectives Research in Multiple Sclerosis (MS) has recently
focused on extracting knowledge from real-world clinical data sources. This type of data is …

Primary progressive multiple sclerosis (PPMS) shows a highly variable disease progression
with poor prognosis and a characteristic accumulation of disabilities in patients. These …

Introduction Reliable measurement of disability in multiple sclerosis (MS) using a
comprehensive, patient self-reported scale, such as the World Health Organization Disability …

Background Generally infrequent, multiple sclerosis (MS) with late onset (LOMS) is
characterized by an onset over the age of 50 and a mainly progressive course, while …

Background Fatigue and disability are indicators of disease progression experienced by
many people with multiple sclerosis (pwMS). Understanding trajectories of these outcomes …

Progressive Multiple Sclerosis : CONTINUUM: Lifelong Learning in Neurology Account
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Abstract Background To compare Expanded Disability Status Scale (EDSS) trajectories over
time between Multiple Sclerosis (MS) groups with pediatric (POMS), adult (AOMS) and late …