Among gut microbiota-derived metabolites, trimethylamine-N-oxide (TMAO) is receiving
increased attention due to its possible role in the carcinogenesis of colorectal cancer (CRC) …

Organic osmolytes are small solutes used by cells of numerous water-stressed organisms
and tissues to maintain cell volume. Similar compounds are accumulated by some …

The study of the interactions of salts and osmolytes with macromolecules in aqueous
solution originated with experiments concerning protein precipitation more than 100 years …

Several neurodegenerative diseases are caused by defects in protein folding, including
Alzheimer, Parkinson, Huntington, and prion diseases. Once a disease-specific protein …

Trimethylamine (TMA) and its N-oxide (TMAO) are ubiquitous in prokaryote and eukaryote
organisms as well as in the environment, reflecting their fundamental importance in …

This paper overviews solution additives that affect protein stability and aggregation during
refolding, heating, and freezing processes. Solution additives are mainly grouped into two …

Organisms experience a wide range of environmental factors such as temperature, salinity
and hydrostatic pressure, which pose challenges to biochemical processes. Studies on …

Despite decades of active research, protein folding remains one of the most important
unsolved problems in molecular biology, and it represents an important missing link …

Since elevated serum levels of trimethylamine N-oxide (TMAO) were first associated with
increased risk of cardiovascular disease (CVD), TMAO research among chronic diseases …

In the context of global climatic changes, marine organisms have been exposed to
environmental stressors including heat and hypoxia. This calls for the design of multi …