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[HTML][HTML] Tau as a biomarker of neurodegeneration
S Holper, R Watson, N Yassi - International Journal of Molecular Sciences, 2022 - mdpi.com
Less than 50 years since tau was first isolated from a porcine brain, its detection in femtolitre
concentrations in biological fluids is revolutionizing the diagnosis of neurodegenerative …
concentrations in biological fluids is revolutionizing the diagnosis of neurodegenerative …
Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer's disease: review, recommendation, implementation and application
Alzheimer's disease (AD) is the most common form of dementia, characterized by
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …
[HTML][HTML] Cholesterol and matrisome pathways dysregulated in astrocytes and microglia
The impact of apolipoprotein E ε4 (APOE4), the strongest genetic risk factor for Alzheimer's
disease (AD), on human brain cellular function remains unclear. Here, we investigated the …
disease (AD), on human brain cellular function remains unclear. Here, we investigated the …
[HTML][HTML] Transcriptome analysis reveals tumor microenvironment changes in glioblastoma
Y Hoogstrate, K Draaisma, SA Ghisai, L van Hijfte… - Cancer cell, 2023 - cell.com
A better understanding of transcriptional evolution of IDH-wild-type glioblastoma may be
crucial for treatment optimization. Here, we perform RNA sequencing (RNA-seq)(n= 322 test …
crucial for treatment optimization. Here, we perform RNA sequencing (RNA-seq)(n= 322 test …
[HTML][HTML] Spatial transcriptomics and in situ sequencing to study Alzheimer's disease
Although complex inflammatory-like alterations are observed around the amyloid plaques of
Alzheimer's disease (AD), little is known about the molecular changes and cellular …
Alzheimer's disease (AD), little is known about the molecular changes and cellular …
A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation
There is currently little information available about how individual cell types contribute to
Alzheimer's disease. Here we applied single-nucleus RNA sequencing to entorhinal cortex …
Alzheimer's disease. Here we applied single-nucleus RNA sequencing to entorhinal cortex …
Transcriptional signature in microglia associated with Aβ plaque phagocytosis
The role of microglia cells in Alzheimer's disease (AD) is well recognized, however their
molecular and functional diversity remain unclear. Here, we isolated amyloid plaque …
molecular and functional diversity remain unclear. Here, we isolated amyloid plaque …
APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids
APOE4 is the strongest genetic risk factor associated with late-onset Alzheimer's disease
(AD). To address the underlying mechanism, we develop cerebral organoid models using …
(AD). To address the underlying mechanism, we develop cerebral organoid models using …
Cell type specific transcriptomic differences in depression show similar patterns between males and females but implicate distinct cell types and genes
Major depressive disorder (MDD) is a common, heterogenous, and potentially serious
psychiatric illness. Diverse brain cell types have been implicated in MDD etiology …
psychiatric illness. Diverse brain cell types have been implicated in MDD etiology …
Molecular subty** of Alzheimer's disease using RNA sequencing data reveals novel mechanisms and targets
Alzheimer's disease (AD), the most common form of dementia, is recognized as a
heterogeneous disease with diverse pathophysiologic mechanisms. In this study, we …
heterogeneous disease with diverse pathophysiologic mechanisms. In this study, we …